Inhibition of Bone Morphogenetic Protein Signal Transduction Prevents the Medial Vascular Calcification Associated with Matrix Gla Protein Deficiency (original) (raw)
Figure 10
Aortic expression of endothelial and multipotency markers in wild-type and MGP-/- mice.
RNA was isolated from aortas of WT and MGP-/- mice and from LDN-193189-treated MGP-/- mice at 7 and 14 days of age (n = 4–8 in each group). Levels of mRNAs encoding endothelial markers (VE-Cadherin and CD31) and multipotency markers (nanog, Oct 3/4, and Sox2) are depicted. The aortas of 14-day-old MGP-/- mice have increased endothelial and multipotency markers compared to WT mice. Treatment with LDN-193189 normalized the endothelial and multipotency markers to WT levels in MGP-/- mice. * P ≤ 0.01 compared to 7-day-old WT mice. # P<0.05 compared to 7-day-old MGP-/- mice.