A γ-Secretase Inhibitor, but Not a γ-Secretase Modulator, Induced Defects in BDNF Axonal Trafficking and Signaling: Evidence for a Role for APP (original) (raw)
Fig 5
BMS-299897, not sGSM41, induces clustering of mitochondria within processes of rat E18 hippocampal neurons.
Samples were prepared as in Fig. 4A. The ultra-structures of hippocampal neurites were examined using transmission electron microscopy as described in Materials and Methods. For each treatment condition, representative images of 9300x, 18500x and Zoom-in are shown. Asterisk denotes a single mitochondrion, arrows point to vesicles. EM data were verified by two independent researchers at the Cellular and Molecular Medicine Electron Microscopy Facility at UCSD.