Secoisolariciresinol Diglucoside Abrogates Oxidative Stress-Induced Damage in Cardiac Iron Overload Condition (original) (raw)
Fig 5
SDG decreases iron-induced MMP gene expression in H9c2 cells.
Gene expression of matrix metalloproteinases in control, 50 μM iron-treated, 500 μM secoisolariciresinol diglucoside (SDG), and SDG pre-treatment + iron-treated H9c2 cells. mRNA levels of matrix metalloproteinase (MMP)-2 (A) and MMP-9 (B) were determined via quantitative real-time PCR and normalized to β2-microglobulin, with normal expression standardized to the control. (*** = p < 0.001 versus control; ** = p < 0.01 versus control, n = 3).