Molecular Dynamics Simulations of the Human Glucose Transporter GLUT1 (original) (raw)
Fig 7
Water transport with substrate through GLUT1.
Representative snapshots of (A) the outward- and (B) the inward-facing conformation through the GLUT1 tunnel during TMD simulations. Water pathways are shown in ball and stick and gray surface map. Glucose molecule is colored in yellow. The water is always isolated either from the extracellular or the intracellular side at any given time so charged molecules could not pass through the transporter during the transport cycle.