Merkel Cell Polyomavirus Small T Antigen Induces Cancer and Embryonic Merkel Cell Proliferation in a Transgenic Mouse Model (original) (raw)
Fig 6
MCV sT expression increases Merkel cell numbers only during embryogenesis.
Wholemount, K8-immunostained skin showing touch domes from control littermate (A, C, F, H, K), Atoh1 CreERT2/+; ROSA sT (B, D, G, I) and Atoh1 CreERT2/+; ROSA sT; p53 flox/flox (L) mice given TMX at P28 (A-D) or E14.5 (F-I, K, L). Age at tissue harvest is shown for each pair of panels. (E, J, M) Graphs showing Merkel cell counts per touch dome for accompanying panels. *p < 0.05, ***p<0.001. Scale bar: 10μm.