Comparative Study of Injury Models for Studying Muscle Regeneration in Mice (original) (raw)
Fig 1
Number of satellite cells and their behaviour in the 4 different injury models.
(A) Number of satellite cells in uninjured, 18h, 1 month and 3 months post-injury; n = 124 animals (ancillary and new data). The figure also displays the number of satellite cells after re-injury (i.e. after two successive lesions carried out 28 days apart; displayed in black histograms) n = 5 animals. (B-E) Percentage of remaining Pax7 positive cells (B) 18h, (C) 2 days, (D) 4 days and (E) 1 month post-injury on TA sections. (F-I) Percentage of cycling Ki67 positive satellite cells (F) 18h, (G) 2 days, (H) 4 days and (I) 1 month after injury. Data are represented as means±s.d. *p < 0.05; **p < 0.01; ***p < 0.001; no star, statistically non significant.