Impaired Inactivation of L-Type Ca2+ Current as a Potential Mechanism for Variable Arrhythmogenic Liability of HERG K+ Channel Blocking Drugs (original) (raw)
Fig 2
Effect of SPX on _I_CaL.
A, Representative traces of _I_CaL during a 200-ms voltage-clamp pulse from −40 to 0 mV before (black) and after (red) exposure to 300 μM SPX. B–C, current–voltage (_I_-V) relationships of _I_peak (■, B) and _I_end of pulse (●, C) under control conditions (black) and after application of 300 μM SPX (red) (n = 10). D, Representative traces of _I_CaL to 1 μM and 10 μM of ketoconazole (blue) (n = 4). E, The comparison of _I_peak (■, left) and _I_s-s (●, right) from _I_CaL before and after 300 μM SPX (n = 10) or 10 μM ketoconazole (n = 4). *P < 0.05 **P < 0.01.