Dapagliflozin, SGLT2 Inhibitor, Attenuates Renal Ischemia-Reperfusion Injury (original) (raw)
Fig 2
Representative kidney section stained for hematoxylin and eosin (H&E) and periodic acid-Schiff (PAS).
(S(n = 5); S + Dapa (n = 5), IR(n = 7), IR + Dapa (n = 7)). (A) H&E stain, yellow arrows indicate cell debri and tubular necrosis. Yellow arrowheads indicate inflammatory cells. Original magnification, 200×. (B) Semi-quantitative analysis of tubule interstitial injury in wild-type and dapagliflozin- and/or albendazole-treated mice 24 h after renal IR injury (C) PAS stain. Yellow arrows indicate necrotized tubules or cast formation. Yellow arrowheads indicate loss of brush border or dilated tubules. Black arrow indicates brush border. Original magnification, 200×. (D) Semi-quantitative analysis of tubular injury in wild-type and dapagliflozin- and/or albendazole-treated mice 24 h after renal IR injury. *P < 0.05 vs. vehicle-treated sham, #P < 0.05 vs. vehicle-treated IR. Bar represents mean ± s.d.