Intestinal Microbiota Promotes Psoriasis-Like Skin Inflammation by Enhancing Th17 Response (original) (raw)
Fig 2
Antibiotic treatment changes the microbiota composition in both BALB/c and C57BL/6 mice.
(a) Comparison of diversity in microbiota between the conventional (CV) and ATB-treated mice using Shannon diversity index. (b) Principal coordinates analysis (PCoA) plot using the unweighted UniFrac distance metric shows the compositional similarity before and after ATB treatment (Day 0, Day 14, Day 21). Each colored orb represents the microbiota composition in feces of one mouse. Each color represents each group of mice at the day 0, 14, 21. (c) The microbial composition in time is displayed as mountain plot before (Day 0) and after ATB treatment (Day 14), and after the induction of skin inflammation (Day 21) in comparison to CV mice. The figure shows (a) means ± SD or (c) means from pool of 5 mice. Statistical significance was determined by unpaired Student t test; *p < 0.05, **p < 0.01.