Preclinical Development of Ipilimumab and Nivolumab Combination Immunotherapy: Mouse Tumor Models, In Vitro Functional Studies, and Cynomolgus Macaque Toxicology (original) (raw)
Fig 2
Immunohistochemistry of MC38 Tumors: Detection of CD3+ T Cells and PD-L1+ Cells on the Tumor Perimeter and Interior.
C57BL/6 mice bearing MC38 tumors (n = 4–5 mice/group) were treated on days 7, 10, and 13 with the indicated antibodies. Tumors were harvested on day 14 and processed for IHC. Sections were stained with anti-CD3 (Abcam SP7 ab16669) or anti-PD-L1 mAbs (14–5982). IHC images of tissue sections derived from the periphery of the tumor (invasive margin) or from within the tumor (interior) are shown.