Renoprotective Effects of Atorvastatin in Diabetic Mice: Downregulation of RhoA and Upregulation of Akt/GSK3 (original) (raw)
Fig 2
Atorvastatin treatment reduces mesangial expansion in db/db mice.
Graphs depict albuminuria (A), glomerular surface area (B), mesangial area, in blue (C) and representative images of a single glomerulus stained with Masson Trichrome (D) from db/+ and db/db mice treated with atorvastatin (10 mg/kg/day for 2 weeks) or control diet. Results are presented as mean ± SEM of 20 glomerular and mesangial areas in sections from 5 mice in each group. *P< 0.05 vs. db/+ control diet, **P<0.05 vs. db/db atorvastatin diet vs. db/db control diet and db/+ atorvastatin diet. (Black scale bar: 10 μm, magnification x100).