Transcriptome analysis of genetically matched human induced pluripotent stem cells disomic or trisomic for chromosome 21 (original) (raw)
Fig 4
Expression of Chr 21 genes in iPSCs and cortical neuronal cultures (trisomic/disomic ratios).
Lines represent individual gene ratios across chromosome 21. Note strong general trend for Chr 21 genes to be over-expressed, although specific genes may be strongly up-or-down regulated depending on cell type. (Black lines indicate 1.5 fold increases or decreases in trisomic cells).