Cadherin-11 contributes to liver fibrosis induced by carbon tetrachloride (original) (raw)
Fig 3
CDH11 deficient mice have attenuated liver fibrosis.
Examination of liver histology using (a) H&E staining, (b) Mason’s Trichome, and (c) Col1-α1 from vehicle treated WT mice (left), CCL4 treated WT mice (middle), and treated with CCL4 treated CDH11_-/-_ mice (right). CDH11 deficiency displayed a reduction in liver fibrosis. Images are representative of 14 mice from each group. Scale bars: 100 μm (a, b); 500 μm (c). Compared to WT, CDH11_-/-_ mice treated with CCL4 have lower (d) histological scores of fibrosis as assessed by Ishak scoring, (e) soluble collagen levels by Sircol, and (f) serum ALT. Data are given as mean +/- SEM, with a total of 14 mice per group performed in 4 independent experiments. (*, p ≤ 0.05 WT Vehicle vs. WT CCL4; #, p ≤ 0.05 WT CCL4 vs. CDH11 -/- CCL4).