Letrozole treatment of pubertal female mice results in activational effects on reproduction, metabolism and the gut microbiome (original) (raw)
Fig 5
Letrozole removal resulted in fasting blood glucose levels and insulin tolerance similar to placebo mice.
Fasting blood glucose (A) and insulin levels (B) were measured for placebo and letrozole-treated mice before (Pre; week 5) and after (Post; week 12) pellet removal (n = 8 placebo, n = 8 letrozole). Removal of the letrozole pellet resulted in normalized fasting blood glucose levels and less elevation of insulin levels compared to before pellet removal. Student t-test was used, * p < 0.05. An insulin tolerance test (ITT) was performed on placebo and letrozole-treated mice after pellet removal (Post; week 12) (C) Removal of the letrozole pellet resulted in a lack of insulin resistance. A repeated measures ANOVA was used for comparing differences between placebo and letrozole mice over time, p < 0.05.