An Antivector Vaccine Protects against a Lethal Vector-Borne Pathogen (original) (raw)
Figure 2
Skin Histological Response in Immunized Mice Infested with Virus-Infected and -Uninfected Ticks
Histological profiles of skin sections taken at d 4 of TBEV-infected I. ricinus tick challenge on Balb/c mice immunized with either TRP2 (A, D), TRP5 (E), or GST (C, F), or unimmunized (B). Stained with hematoxylin and eosin (A–D) or “Hema Gurr” Rapid stain BDH (E, F) [19]. (A) (magnification 20×) TRP2-immunized animals, (B) (magnification 20×) control unimmunized, and (C) (magnification 20×) GST-immunized animals. Ep, epidermis; De, dermis; CC, cement cone of I. ricinus. (D–E) (magnification 63×) denote skin sections from TRP2 and TRP5 immunized mice, respectively, showing: perivascular cuffing = yellow circle; degranulating mast cells = green arrow; numerous lymphocytes = blue arrow; frequent macrophages = yellow arrow; and some eosinophils = white arrow; dermal dendrocytes = black arrow; neutrophils = gray arrow; and basophils = light blue arrow. (F) (magnification 63×) skin sections from GST control immunized mice showing lymphocytes, macrophages, and dermal dendrocytes.