Insertion Sequence–Driven Diversification Creates a Globally Dispersed Emerging Multiresistant Subspecies of E. faecium (original) (raw)
Figure 2
Complete Linkage Hierarchical Clustering of E. faecium Inserts with Pearson Correlation and Euclidian Distance, Zoom on Accessory Insert
The hierarchical clustering of inserts visualizes composition of the microbial pangenome: the core genome and accessory genes. The lower panel of the figure represents a zoomed-in accessory genome, as indicated by the vertical and diagonal arrows in the middle of the figure. Presence of an insert is indicated in red and absence of an insert in green. Inserts are clustered on the _x_-axis, and strains are presented on the _y_-axis (indicated by a vertical arrow left of the lower panel). Horizontal straight lines separate the hospital clade strains (H) from the non-hospital clade strains. The core genome and accessory genes are indicated by a blue and purple bar, respectively. Hospital clade–associated clustered inserts are indicated with pink bars.