Critical Loss of the Balance between Th17 and T Regulatory Cell Populations in Pathogenic SIV Infection (original) (raw)
Figure 5
Differential dynamics of Tregs after acute SIV infection of PTs and AGMs.
Frequency (A) and absolute number (B) of FoxP3+CD4+ T cells amongst total CD4+ T cells in PBMCs. (C) FACS detection of FoxP3 and Ki67 in peripheral blood CD4+ T cells as a function of time after infection in a representative PT (A99059) and AGM (06006). (D) Frequency of FoxP3+ cells in the lymph nodes both within CD4+ T cells. Quantitative analysis (E) and immunohistochemistry (F) of FoxP3-expressing cells within the paracortical T cell zone of lymph nodes (left) and in the lamina propria of colon biopsies (right). Refer to Figure 1 for a description of statistical analysis and symbols.