Studies of a Ring-Cleaving Dioxygenase Illuminate the Role of Cholesterol Metabolism in the Pathogenesis of Mycobacterium tuberculosis (original) (raw)
Figure 6
Growth of Δ_hsaC_ mutant in the guinea pig model of tuberculosis.
(A) Growth kinetics in the lung and spleen of guinea pigs aerosol-infected with H37Rv, Δ_hsaC_ mutant, or the complemented Δ_hsaC_ mutant (n = 15 guinea pigs per group). Asterisks indicate significant (*p<0.05) or highly significant (**p<0.01) differences found between guinea pigs infected with the H37Rv wild-type and Δ_hsaC_ mutant strain. (B) Gross pathology of guinea pig lungs infected with wild-type, mutant, and complemented strains at week 4 and week 8. (C) Histopathological appearance of same lung specimens as those depicted in (B).