Accurate Prediction of Secreted Substrates and Identification of a Conserved Putative Secretion Signal for Type III Secretion Systems (original) (raw)
Figure 1
Accurate identification of type III secreted effectors using sequence data.
The sensitivity (TP/(TP+FN); solid lines) and specificity (TN/(FP+TN); dashed lines) of SIEVE on S. Typhimurium predictions (PSY to STM model; red) and P. syringae (STM to PSY model; blue) effectors were calculated as a function of a SIEVE score threshold (X axis). The results show that both models perform well providing a maximum sensitivity and specificity at about 90%. For example 33 of 36 known S. Typhimurium effectors are in the top 10% of predictions.