P58IPK: A Novel “CIHD” Member of the Host Innate Defense Response against Pathogenic Virus Infection (original) (raw)
Figure 6
P58IPK−/− mice exhibit increased mortality to pandemic influenza virus infection yet similar levels of virus replication.
(A) Three P58IPK−/− and wild-type mice were infected with 105 or 5×106 PFU of the r1918 strain of influenza virus. The number of surviving mice, as determined by having at least 20% of starting weight, at each day is shown. (B) Three P58IPK−/− and wild-type mice infected with 104 PFU of r1918 were sacrificed at 3 days post infection. Levels of infectious virions in diaphragmatic lung homogenates were determined by triplicate plaque assay on MDCK cells. The results represent the mean activity of 3 independent samples±standard deviation.