Anopheles gambiae PGRPLC-Mediated Defense against Bacteria Modulates Infections with Malaria Parasites (original) (raw)
Figure 1
Resistance of PGRP kd mosquitoes and mutant fruit flies to bacterial infections.
(A) Kaplan Meier survival curves of adult A. gambiae females silenced for PGRP gene expression, and infected 4 days later with E. coli (left) or S. aureus (right). PGRPS2 and S3 were concomitantly silenced using dsRNA that fully matched both sequences. Survival was recorded daily for 9 days and compared to that of GFP dsRNA-injected controls. The data are the average of very similar results obtained from at least three replicate infections. (B) Kaplan Meier survival curves of adult D. melanogaster females of the PGRP-SAseml, PGRP-LC− and white (control) mutant strains infected with E. coli (left) or S. aureus (right).