Continuous Quinacrine Treatment Results in the Formation of Drug-Resistant Prions (original) (raw)
Figure 2
Immunohistochemical analyses of brain sections from quinacrine-treated, RML-infected MDR0/0[60–90] mice.
Brain sections were prepared from treated and untreated MDR0/0 mice that were sacrificed 60, 75, and 90 dpi as well as from mice at the endpoint of disease. Sections were taken from nearly identical regions of the cortex (ctx), hippocampus (hip) and thalamus (thal), then immunostained for the glial fibrillary acidic protein (GFAP) to visualize astrocytic gliosis. Scale bar represents 50 µm and applies to all panels.