Fine-Tuning Translation Kinetics Selection as the Driving Force of Codon Usage Bias in the Hepatitis A Virus Capsid (original) (raw)
Figure 7
HAV anticodon usage variation in the capsid coding region during the adaptation to 0.2 µg/ml of AMD.
Passage 65 of the population adapted to 0.05 µg/ml of AMD was thereafter passaged in the presence of 0.2 µg/ml of the drug (lineage 2; right column). Left column depicts the behavior of the population in the absence of AMD as baseline control. The percentage of variation of each individual viral anticodon in the mutant spectra with respect to the cellular usage is shown. Mean and standard deviation of the variation of use of those anticodons with the highest level of variation (encircled) is shown.