SARS-CoV Pathogenesis Is Regulated by a STAT1 Dependent but a Type I, II and III Interferon Receptor Independent Mechanism (original) (raw)
Figure 3
In situ hybridization of rMA15 infected mouse lungs.
A. Paraffin embedded mouse lungs where sectioned and probed with S35 labeled probe complementary to SARS-CoV nucleocapsid RNA. Representative samples from days 2, 5 and 9 post-infection (dpi) are shown. Not shown are slides probed with a non-specific probe, which showed no labeling at all. Mock infected samples also showed no labeling. B. High magnification image of a 9 day post-infection STAT1−/− mouse lung with a corresponding H&E stained slide next to it. Note that areas with in situ signal overlap with areas of infiltration in the H&E stained section.