SARS-CoV Pathogenesis Is Regulated by a STAT1 Dependent but a Type I, II and III Interferon Receptor Independent Mechanism (original) (raw)
Figure 5
Pathogenesis of Urbani and rMA15 viruses in IL28Ra−/− mice.
BALB/c and IL28Ra−/− mice were infected with 1×105 pfu of either Urbani or rMA15 virus. A. Real time analysis of IL28B transcripts was performed on WT 129 infected mice at 2, 5 and 9 days post infection. Graphed is the fold increase over 18S RNA for each mouse with 5 mice at each timepoint averaged together. B. Titer of Urbani and rMA15 virus at each timepoint. Lungs were homogenized and supernatant of each lung was titered by plaque assay on Vero cells. Shown is the average titer from 5 mice at each timepoint. The level of detection is shown by a dotted line at 100 pfu/ml.