SARS-CoV Pathogenesis Is Regulated by a STAT1 Dependent but a Type I, II and III Interferon Receptor Independent Mechanism (original) (raw)
Figure 6
IFNL receptor antibody treatment of IFNAR1−/− mice.
IFNAR1−/− mice were treated with 100µg of anti-IL28Ra antibody and infected with rMA15 virus. A. Mock infected (PBS) and antibody injected IFNAR1−/− mice were infected with 1×105 pfu/ml rMA15 virus at day 0. Average weights for each group are plotted compared to starting weights (5 mice per group). B. Mouse lungs were harvested at days 2, 4 and 9 post-infection. Virus titer in lung homogenates were determined on Vero cells. 5 mice were used per timepoint and the average titer of the group of 5 mice is shown.