Early Severe Inflammatory Responses to Uropathogenic E. coli Predispose to Chronic and Recurrent Urinary Tract Infection (original) (raw)
Figure 2
The outcome of UPEC infection of the urinary bladder differs between C3H/HeOuJ and C3H/HeJ mice.
C3H/HeOuJ (closed circles) or C3H/HeJ (open circles) mice were infected with 107 cfu UTI89 KanR and followed for 4 wpi. Data were compiled from two independent experiments. A, Urine bacterial titers were assayed over 4 wpi. Solid lines connect the urine titers over time for each individual mouse. Dashed horizontal line represents the cutoff for significant bacteriuria in free catch urines: 104 cfu/ml. B–C, B, Bladder and C, Kidney titers were assayed at 4 wpi; D, Bladders with high bacterial burdens (>104 cfu from panel B) were weighed at 4 wpi. All statistics in panels B, C, and D are the results of a two-tailed Mann-Whitney U test: **, P<0.01, ***, P<0.001 and ns, not significant; horizontal bars indicate median values.