Host Imprints on Bacterial Genomes—Rapid, Divergent Evolution in Individual Patients (original) (raw)
Figure 1
Genetic map of the E. coli 83972 chromosome and the small plasmid pABU.
Nucleotide sequence analysis of the E. coli 83972 chromosome a): The two most outer circles represent all putative open reading frames (ORFs), depending on ORF orientation. The following five circles report the results of a two-way genome comparison between E. coli 83972 and one of the following E. coli strains: CFT073 (UPEC), 536 (UPEC), UTI89 (UPEC), MG1655 (K-12) and Sakai (EHEC O157:H7). Genes shared between the strain pair compared are indicated in grey and variable genome regions are indicated in red. The innermost circle represents the G+C distribution. Genomic regions only present in strains ABU83972 and CFT073 are framed in red. Chromosomal segments framed in green or blue are only present in the ABU isolate and pathogenic E. coli or represent bacteriophage-related DNA, respectively. Details on the gene content of these regions are compiled in Table 1. UPEC, uropathogenic E. coli; EHEC, enterohemorrhagic E. coli. Nucleotide sequence analysis of plasmid pABU b): putative predicted ORFs have been indicated.