Blockade of Immunosuppressive Cytokines Restores NK Cell Antiviral Function in Chronic Hepatitis B Virus Infection (original) (raw)
Figure 2
Skewed NK cell effector function in CHB is only partially corrected during therapy.
(Panels A–C) Representative density plots from a healthy control and HBV patients with low ALT (ALT <50 IU/L, median 33) and raised ALT (ALT>50 IU/L, median 112) and summary data for TRAIL expression, IFN-γ production and CD107 expression. (D) Summary bar charts of CD56bright proportions, NK cell TRAIL expression and NK cell IFN-γ production from healthy, CHB and patients on antiviral therapy. Results are expressed as mean ± SEM. Rx = treated patients. *p<0.05, **p<0.01, ***p<0.001 by Mann-Whitney test.