SUMO Pathway Dependent Recruitment of Cellular Repressors to Herpes Simplex Virus Type 1 Genomes (original) (raw)
Figure 10
The SIMs of PML and hDaxx are required for repression of ICP0 null mutant HSV-1 plaque formation.
A. Relative plaque forming efficiencies of wt (upper histogram) and ICP0-null mutant (lower histogram) HSV-1 in control and hDaxx-depleted cells and in cells reconstituted with the wt and mSIM mutant proteins. The data show means and standard deviations from 3 independent experiments. The statistical significance between the ICP0 null mutant plaque forming efficiencies in wt and mSIM mutant reconstituted cells is marked (Student's two-tailed t-Test, p = <0.05). B. As in A, except using control, PML-depleted and the indicated PML reconstituted cell lines. The data show means and standard deviations from 5 independent experiments. Statistical significance shown as in A (Student's two-tailed t-Test, p = <0.001).