The Legionella IcmSW Complex Directly Interacts with DotL to Mediate Translocation of Adaptor-Dependent Substrates (original) (raw)
Figure 8
Model for secretion of IcmS/IcmW-dependent effectors by DotL.
The transmembrane-spanning L. pneumophila T4SS complex is represented by a purple cylinder, components of the T4CP subcomplex (DotL, DotM, IcmS, and IcmW) are labeled and the inner and outer membranes are indicated as IM and OM, respectively. (A) Export of IcmSW-dependent substrates in a wild type strain. (B) Rejection of IcmSW-dependent substrates in a dotL mutant strain that lacks the IcmSW-dependent binding domain (dotL_−S/W). (C) Jamming of IcmSW-dependent substrates in a Δ_icmS mutant, leads to DotL degradation by ClpAP.