Relative Contribution of Th1 and Th17 Cells in Adaptive Immunity to Bordetella pertussis: Towards the Rational Design of an Improved Acellular Pertussis Vaccine (original) (raw)
Figure 2
Protective immunity induced with Pw is mediated by IFN-γ and IL-17.
WT, IFN-γ−/− or IL-17A−/− mice were immunized i.p. twice (0 and 28 days) with Pw. 14 days after the second immunization, mice were challenged by exposure to an aerosol of live B. pertussis. (A) The number of CFU in the lungs were quantified at intervals after challenge. (B) _B. pertussis_-specific cytokine production by spleen cells on day of challenge. *p<0.05, **p<0.01, ***p<0.001 IFN-γ−/− or IL-17A−/− versus WT. Results are mean values for 4 mice per group at each time point and each panel is representative of 2 independent experiments.