Malaria Parasite-Synthesized Heme Is Essential in the Mosquito and Liver Stages and Complements Host Heme in the Blood Stages of Infection (original) (raw)
Figure 7
Ability of P.berghei sporozoites (WT and KOs) to infect mice with and without ALA supplement to the animals.
Mosquitoes were allowed to feed on mice (30 mosquitoes/mouse) and parasitemia in blood and mortality of the animals were assessed. The data represent 9 mice each from three different batches. Mq, mosquito; Mi, mice; _Pb_ALASKO(Mq+ALAMi+ALA), _Pb_ALASKO supplemented with ALA in mosquitoes and mice; _Pb_ALASKO(Mq+ALAMi−ALA), _Pb_ALASKO supplemented with ALA in mosquitoes but not in mice; _Pb_FCKO(Mq+Blood), _Pb_FCKO supplemented with blood feeding in mosquitoes.