Functional Specialization of the Small Interfering RNA Pathway in Response to Virus Infection (original) (raw)
Figure 2
vsiRNA abundance is dependent on Dcr-2 but not Loqs-PD.
(A) Levels of the genome RNA strand, antigenome RNA strand, and total virus RNA from VSV and SINV infected animals 48 hours post infection. The polarity of SINV and VSV genomes are indicated. (B,C) Normalized levels of sequenced small RNAs of different size that match the VSV (B) and SINV (C) genomes. Shown are levels after infection of wildtype (wt), Dcr-2, R2D2 and loqs mutants. Bars above the midline denote positive-stranded small RNAs, and bars below the midline denote negative-stranded small RNAs.