Broad-Spectrum Anti-biofilm Peptide That Targets a Cellular Stress Response (original) (raw)
Figure 2
Low levels of 1018 led to biofilm dispersion while higher levels triggered biofilm cell death.
Dispersed cells from mature P. aeruginosa flow cell biofilms were collected and viable cell counts performed after 0, 3 and 23 h of treatment with different concentrations of the peptide (0.8 and 10 µg/ml). Representative confocal images of the remaining cells present in the flow cell chambers after peptide treatment are shown for each condition. Statistical significance comparing peptide-treated groups to untreated was determined using Student's t test (ns, P>0.05; *, P<0.05; **, P<0.01; ****, P<0.0001).