Modulation of the Host Lipid Landscape to Promote RNA Virus Replication: The Picornavirus Encephalomyocarditis Virus Converges on the Pathway Used by Hepatitis C Virus (original) (raw)
Fig 8
Evolution of the recruitment of lipid-modulating pathways by picorna- and flaviviruses.
Our current understanding of the major elements of lipid-modulating pathways targeted by proteins of picorna- and flaviviruses in the context of the virus phylogeny is presented. Only viruses characterized so far with respect to this function are depicted. The tree branches are of arbitrary scale, while the branching of picornaviruses reflects the topology of maximum-likelihood RdRp-based tree according to Gorbalenya & Lauber, 2010 [80], and the entire tree is rooted according to Gibrat et al., 2013 [81]. *In addition to NS5A, NS5B has also been suggested to be involved in the interaction with PI4KA [24,46]. Abbreviation of virus names are as follows: DENV, dengue virus; HCV, hepatitis C virus; EMCV, encephalomyocarditis virus; ERAV, equine rhinitis A virus; CV, coxsackievirus; PV, poliovirus; RV, rhinovirus; AiV, Aichivirus; HAV, hepatitis A virus.