The Salmonella Effector Protein SopA Modulates Innate Immune Responses by Targeting TRIM E3 Ligase Family Members (original) (raw)
Fig 6
Proposed model for SopA action.
After its delivery by the S. Typhimurium type III secretion system, SopA targets TRIM56 and/or TRIM65 and through ubiquitination, enhances their ability to modulate RIG-I and/or MDA-5-dependendant signal transduction pathways leading to pro-inflammatory cytokine production. The modulatory activity of SopA may require the prior stimulation of RIG-I and/or MDA-5 by other agonists such as nucleic acids.