Vaccination has minimal impact on the intrahost diversity of H3N2 influenza viruses (original) (raw)
Fig 3
Intrahost diversity in samples from the 2007–2008 season.
(A) Histogram of the number of iSNV at a given frequency. Bin width = 0.01. (B) Histogram of the number of samples in which each iSNV is found. Arrows indicate bars with one SNV, which are hard to discern in the histogram. These polymorphic SNV, at PB2 position 900 and PA position 515 respectively, were found at 4–6% frequency within hosts and in similar numbers of individuals across vaccination groups. (C) Number of HA iSNV per sample stratified by pre-season HAI titer. >40 = serologically immune, <40 = not serologically immune. (D) Number of NA iSNV per sample stratified by pre-season NAI titer. ≥40 = serologically immune, <40 = not serologically immune.