A novel Zika virus mouse model reveals strain specific differences in virus pathogenesis and host inflammatory immune responses (original) (raw)
Fig 3
Comparison of weight loss and mortality induced by African and Asian ZIKV strains in mice.
Five to six week old male WT, Stat2 -/- and Ifnar1 -/- C57BL/6 mice (n = 5) were injected with 1,000 PFU of the indicated ZIKV strain by the subcutaneous route in the footpad. (A, B) Mice were weighed daily and weights are expressed as percentage of body weight prior to infection. Results shown are the mean ± standard error of the mean (SEM). (A) Data are censored at 6 days after infection, as some mice died. (C, D) In a parallel group, male mice (n = 5) of the indicated genotype were infected with indicated ZIKV strains under similar conditions and data were combined with body weight loss group for survival analysis (total n = 10). ZIKV strains are abbreviated as UG (Uganda), SN (Senegal), ML (Malaysia), CB (Cambodia) and PR (Puerto Rico).