A VP1 mutation acquired during an enterovirus 71 disseminated infection confers heparan sulfate binding ability and modulates ex vivo tropism (original) (raw)
Fig 7
Viral infectivity of EV71-VP1 97R167G and EV71-VP1 97L167E in Vero cells (A) and of EV71-VP1 97R167G , EV71-VP1 97L167E and EV71-VP1 97L/R167E/G in neural cells (B) in the presence of increasing doses of ı-carrageenan. The percent of infection was measured by an immunocytochemistry assay in Vero cells (A) and by RT-qPCR on cell lysate 1 dpi in neural cells (B) and expressed as the mean (±SEM) compared to non-treated viruses. (N = 2). **P<0.005. The frequency plots are shown on the right (see Fig 3 for details).