Hepatitis B e antigen induces the expansion of monocytic myeloid-derived suppressor cells to dampen T-cell function in chronic hepatitis B virus infection (original) (raw)
Fig 1
Frequency of circulating mMDSCs in CHB patients.
(A) Sequential gating strategy for mMDSC identification (HLA-DR-/low CD33+CD11b+CD14+) from PBMCs. (B) Representative data plots of mMDSCs from CHB patients in different disease phase including IT, IA+, IC and IA-. The boxed areas represent the mMDSCs in PBMCs. (C) Statistical analysis of mMDSCs frequency in PBMCs and (D) in CD14+ monocytes from CHB patients and healthy controls. (E) The numbers of mMDSCs in PBMCs from CHB patients and healthy controls. (F) Comparison of mMDSCs frequency in PBMCs and (G) in CD14+ monocytes from CHB patients in different disease phase. (H) The numbers of mMDSCs in PBMCs from CHB patients. Horizontal lines and error bars represent mean ± SEM.