Oxamniquine resistance alleles are widespread in Old World Schistosoma mansoni and predate drug deployment (original) (raw)
Fig 2
Mapping of the resistance mutations on the gene sequence and structure of Schistosoma mansoni SmSULT-OR sulfotransferase.
Exon 1 and exon 2 are represented in orange and beige, respectively. Single nucleotide polymorphisms and duplication/deletion events are represented in cyan and magenta, respectively. (A) Linear representation of the SmSULT-OR gene showing the relative position of the mutations and their translation in amino acid sequences. (B) Positions of mutations on the SmSULT-OR protein. Oxamniquine is represented in yellow, 3’-phosphoadenosine-5’-phosphosulfate (PAPS) co-factor is represented in green.