Oxamniquine resistance alleles are widespread in Old World Schistosoma mansoni and predate drug deployment (original) (raw)
Fig 4
In silico evaluation of mutations on protein stability.
We computed the difference in free enthalpy (ΔΔG) between the mutated and the wild type proteins. The higher the ΔΔG, the more unstable is the mutated protein. Only single amino acid changes within the resolved crystal structure were examined. For completeness, we included mutations from our current dataset and from previous studies [10,13]. Grey bars correspond to known sensitive alleles. Red bars correspond to validated resistance alleles. Grey labels correspond to mutations identified previously from South America [13].