Selenium and Mortality in the Elderly: Results from the EVA Study (original) (raw)

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N Tasnime Akbaraly ,

Institut National de la Santé et de la Recherche Médicale E0361

, Pathologies du Système Nerveux: Recherche Épidémiologique et Clinique; Université Montpellier I. Hôpital La Colombière, Montpellier, France

Address correspondence to this author at: Institut National de la Santé et de la Recherche Médicale E0361, Hôpital La Colombière, 39, Ave. Charles Flahault, BP 34493, 34093 Montpellier Cedex 5, France. Fax 33-(0)4-99-614-579; e-mail [email protected].

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Josiane Arnaud ,

NVMC (Unité de Nutrition Vieillissement et Maladie Cardiovasculaires)

, UFR de Pharmacie, Joseph Fourrier, Grenoble, France

Département de Biologie Intégrée

, CHU de Grenoble, Grenoble, France

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Isabelle Hininger-Favier ,

NVMC (Unité de Nutrition Vieillissement et Maladie Cardiovasculaires)

, UFR de Pharmacie, Joseph Fourrier, Grenoble, France

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Veronique Gourlet ,

Institut National de la Santé et de la Recherche Médicale U708

, Neuroepidemiologie, GH Pitié Salpétrière, Paris, France

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Anne-Marie Roussel ,

NVMC (Unité de Nutrition Vieillissement et Maladie Cardiovasculaires)

, UFR de Pharmacie, Joseph Fourrier, Grenoble, France

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Claudine Berr

Institut National de la Santé et de la Recherche Médicale E0361

, Pathologies du Système Nerveux: Recherche Épidémiologique et Clinique; Université Montpellier I. Hôpital La Colombière, Montpellier, France

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Published:

01 November 2005

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N Tasnime Akbaraly, Josiane Arnaud, Isabelle Hininger-Favier, Veronique Gourlet, Anne-Marie Roussel, Claudine Berr, Selenium and Mortality in the Elderly: Results from the EVA Study, Clinical Chemistry, Volume 51, Issue 11, 1 November 2005, Pages 2117–2123, https://doi.org/10.1373/clinchem.2005.055301
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Abstract

Background: Inadequate plasma selenium can adversely affect the maintenance of optimal health; therefore, reported decreases in plasma selenium in an aging population are cause for concern. To further examine this hypothesis, we explored the relationships between plasma selenium and mortality in an elderly population: the EVA (Etude du Vieillissement Artériel) study.

Methods: The EVA study was a 9-year longitudinal study with 6 periods of follow-up. During the 2-year period from 1991 to 1993 (EVA0), 1389 men and women born between 1922 and 1932 were recruited. The effects of plasma selenium at baseline on mortality were determined by Cox proportional hazards regression analysis, adjusting for the following variables: sociodemographic characteristics, dietary habits, health, and cognitive factors.

Results: During the 9-year follow-up, 101 study participants died. Baseline plasma selenium was higher in individuals who were alive at the end of follow-up [mean (SD), 1.10 (0.20) μmol/L] than in those who died during the follow-up [1.01 (0.20) μmol/L; P <10−4]. Mortality rates were significantly higher in individuals with low selenium [increments = 0.2 μmol/L; relative risk (RR) = 1.56 (95% confidence interval, 1.28–1.89)]. After we controlled for various potential confounding factors, this association remained significant [RR = 1.54 (1.25–1.88)]. When the underlying causes of death were considered, we found an association with cancer-related mortality [adjusted RR = 1.79 (1.32–2.44)].

Conclusions: Even if it is premature to present selenium as a longevity indicator in an elderly population, our results are in accordance those of large, interventional, randomized trials with selenium, which suggest that this essential trace element plays a role in health maintenance in aging individuals.

© 2005 The American Association for Clinical Chemistry

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