Mood stabilizers target cellular plasticity and resilience cascades (original) (raw)

• Tohen M., Hennen J., Zarate C. M. Jr., et al. (2000) Two-year syndromal and functional recovery in 219 cases of first-episode major affective disorder with psychotic features. Am. J. Psychiatry 157, 220–228.
  Article PubMed CAS Google Scholar
• Benazzi F. (2001) Prevalence and clinical correlates of residual depressive symptoms in bipolar II disorder. Psychother. Psychosom. 70, 232–238.
  Article PubMed CAS Google Scholar
• Keitner G. I., Solomon D. A., Ryan C. E., et al. (1996) Prodromal and residual symptoms in bipolar I disorder. Compr. Psychiatry 37, 362–367.
  Article PubMed CAS Google Scholar
• Gitlin M. J., Swendsen J., Heller T. L., and Hammen C. (1995) Relapse and impairment in bipolar disorder. Am. J. Psychiatry 152, 1635–1640.
  PubMed CAS Google Scholar
• Zarate C. A. Jr., Tohen M., Land M., and Cavanagh S. (2000) Functional impairment and cognition in bipolar disorder. Psychiatr. Q. 71, 309–329.
  Article PubMed Google Scholar
• MacQueen G. M., Young L. T., and Joffe R. T. (2001) A review of psychosocial outcome in patients with bipolar disorder. Acta. Psychiatr. Scand. 103, 163–170.
  Article PubMed CAS Google Scholar
• Murray C. J. and Lopez A. D. (1997) Alternative projections of mortality and disability by cause 1990–2020: Global Burden of Disease Study. Lancet 349, 1498–1504.
  Article PubMed CAS Google Scholar
• Musselman D. L., Evans D. L., and Nemeroff C. B. (1998) The relationship of depression to cardiovascular disease: epidemiology, biology, and treatment. Arch. Gen. Psychiatry 55, 580–592.
  Article PubMed CAS Google Scholar
• Michelson D., Stratakis C., Hill L., et al. (1996) Bone mineral density in women with depression. N. Engl. J. Med. 335, 1176–1181.
  Article PubMed CAS Google Scholar
• Ciechanowski P. S., Katon W. J., and Russo J. E. (2000) Depression and diabetes: impact of depressive symptoms on adherence, function, and costs. Arch. Intern. Med. 160, 3278–3285.
  Article PubMed CAS Google Scholar
• Gould T. D. and Manji H. K. (2002) Signaling networks in the pathophysiology and treatment of mood disorders. J. Psychosom. Res. 53, 687–697.
  Article PubMed Google Scholar
• Manji H. K., Bebchuk J. M., Moore G. J., Glitz D., Hasanat K. A., and Chen G. (1999) Modulation of CNS signal transduction pathways and gene expression by mood-stabilizing agents: therapeutic implications. J. Clin. Psychiatry 60, 27–39; discussion 40–21, 113–116.
  PubMed Google Scholar
• Manji H. K., Chen G., Hsiao J. K., Risby E. D., Masana M. I., and Potter W. Z. (1996) Regulation of signal transduction pathways by mood-stabilizing agents: implications for the delayed onset of therapeutic efficacy. J. Clin. Psychiatry 57, 34–46; discussion 47–38.
  PubMed CAS Google Scholar
• Chen G., Manji H. K., Hawver D. B., Wright C. B., and Potter W. Z. (1994) Chronic sodium valproate selectively decreases protein kinase C alpha and epsilon in vitro. J. Neurochem. 63, 2361–2364.
  Article PubMed CAS Google Scholar
• Williams R. S., Cheng L., Mudge A. W., and Harwood A. J. (2002) A common mechanism of action for three mood-stabilizing drugs. Nature 417, 292–295.
  Article PubMed CAS Google Scholar
• Lenox R. H., McNamara R. K., Watterson J. M., and Watson D. G. (1996) Myristoylated alanine-rich C kinase substrate (MARCKS): a molecular target for the therapeutic action of mood stabilizers in the brain? J. Clin. Psychiatry 57, 23–31; discussion 32–33.
  PubMed CAS Google Scholar
• Lenox R. H. and Wang L. (2003) Molecular basis of lithium action: integration of lithium-responsive signaling and gene expression networks. Mol. Psychiatry 8, 135–144.
  Article PubMed CAS Google Scholar
• Coyle J. T. and Duman R. S. (2003) Finding the intracellular signaling pathways affected by mood disorder treatments. Neuron 38, 157–160.
  Article PubMed CAS Google Scholar
• Harwood A. J. and Agam G. (2003) Search for a common mechanism of mood stabilizers. Biochem. Pharmacol. 66, 179–189.
  Article PubMed CAS Google Scholar
• Post R. M. (2000) Psychopharmacology of mood stabilizers. In: Schizophrenia and Mood Disorders: The New Drug Therapies in Clinical Practice., Buckley P. F. and Waddington J. L., eds. Oxford: Butterworth-Heinemann, pp. 127–154.
  Google Scholar
• Ryves W. J. and Harwood A. J. (2001) Lithium inhibits glycogen synthase kinase-3 by competition for magnesium. Biochem. Biophys. Res. Commun. 280, 720–725.
  Article PubMed CAS Google Scholar
• Davies S. P., Reddy H., Caivano M., and Cohen P. (2000) Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem. J. 351, 95–105.
  Article PubMed CAS Google Scholar
• Amari L., Layden B., Rong Q., Geraldes C. F., and Mota de Freitas D. (1999) Comparison of fluorescence, (31)P NMR, and (7)Li NMR spectroscopic methods for investigating Li(+)/Mg(2+) competition for biomolecules. Anal. Biochem. 272, 1–7.
  Article PubMed CAS Google Scholar
• York J. D., Ponder J. W. and Majerus P. W. (1995) Definition of a metal-dependent/Li(+)-inhibited phosphomonoesterase protein family based upon a conserved three-dimensional core structure. Proc. Natl. Acad. Sci. USA 92, 5149–5153.
  Article PubMed CAS Google Scholar
• Masuda C. A., Xavier M. A., Mattos K. A., Galina A., and Montero-Lomeli M. (2001) Phosphoglucomutase is an in vivo lithium target in yeast. J. Biol. Chem. 10, 10.
  Google Scholar
• Kajda P. K. and Birch N. J. (1981) Lithium inhibition of phosphofructokinase. J. Inorg. Biochem. 14, 275–278.
  Article PubMed CAS Google Scholar
• Klein P. S. and Melton D. A. (1996) A molecular mechanism for the effect of lithium on development. Proc. Natl. Acad. Sci. USA 93, 8455–8459.
  Article PubMed CAS Google Scholar
• Johannessen C. U. (2000) Mechanisms of action of valproate: a commentatory. Neurochem. Int. 37, 103–110.
  Article PubMed CAS Google Scholar
• van der Laan J. W., de Boer T., and Bruinvels J. (1979) Di-n-propylacetate and GABA degradation. Preferential inhibition of succinic semialdehyde dehydrogenase and indirect inhibition of GABA-transaminase. J. Neurochem. 32, 1769–1780.
  Article PubMed Google Scholar
• Sawaya M. C., Horton R. W., and Meldrum B. S. (1975) Effects of anticonvulsant drugs on the cerebral enzymes metabolizing GABA. Epilepsia 16, 649–655.
  PubMed CAS Google Scholar
• Whittle S. R. and Turner A. J. (1978) Effects of the anticonvulsant sodium valproate on gamma-aminobutyrate and aldehyde metabolism in ox brain. J. Neurochem. 31, 1453–1459.
  Article PubMed CAS Google Scholar
• Anlezark G. M., Horton R. W., Meldrum B. S., Sawaya M. C., and Stephenson J. D. (1976) Proceedings: gamma-aminobutyric acid metabolism and the anticonvulsant action of ethanolamine-o-sulphate and di-n-propylacetate. Br. J. Pharmacol. 56, 383P,384P.
• Gottlicher M., Minucci S., Zhu P., et al. (2001) Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells. Embo. J. 20, 6969–6978.
  Article PubMed CAS Google Scholar
• Tremolizzo L., Carboni G., Ruzicka W. B., et al. (2002) An epigenetic mouse model for molecular and behavioral neuropathologies related to schizophrenia vulnerability. Proc. Natl. Acad. Sci. USA 99, 17,095–17,100.
  Article CAS Google Scholar
• Yildirim E., Zhang Z., Uz T., Chen C. Q., Manev R., and Manev H. (2003) Valproate administration to mice increases histone acetylation and 5-lipoxygenase content in the hippocampus. Neurosci. Lett. 345, 141–143.
  Article PubMed CAS Google Scholar
• Gould T. D., Chen G., and Manji H. K. (2003) In Vivo Evidence in the Brain for Lithium Inhibition of Glycogen Synthease Kinase-3. In Neuropsychopharmacology.
• Bourne H. R. and Nicoll R. (1993) Molecular machines integrate coincident synaptic signals. Cell 72(Suppl), 65–75.
  Article PubMed Google Scholar
• Bhalla U. S. and Iyengar R. (1999) Emergent properties of networks of biological signaling pathways. Science 283, 381–387.
  Article PubMed CAS Google Scholar
• Weng G., Bhalla U. S., and Iyengar R. (1999) Complexity in biological signaling systems. Science 284, 92–96.
  Article PubMed CAS Google Scholar
• Manji H. K. (1992) G proteins: implications for psychiatry. Am. J. Psychiatry 149, 746–760.
  PubMed CAS Google Scholar
• Szabo S. T., Gould T. D., and Manji H. K. (2003) Introduction to neurotransmitters, receptors, signal transduction, and second messengers. In: Textbook of Psychopharmacology, Nemeroff C., ed. Arlington, VA: American Psychiatric Publishing, pp. 3–52.
  Google Scholar
• Rasenick M. M., Chaney K. A., and Chen J. (1996) G protein-mediated signal transduction as a target of antidepressant and antibipolar drug action: evidence from model systems. J. Clin. Psychiatry 57, 49–55; discussion 56–58.
  PubMed CAS Google Scholar
• Berridge M. J., Downes C. P., and Hanley M. R. (1989) Neural and developmental actions of lithium: a unifying hypothesis. Cell 59, 411–419.
  Article PubMed CAS Google Scholar
• Allison J. H., Blisner M. E., Holland W. H., Hipps P. P., and Sherman W. R. (1976) Increased brain myo-inositol 1-phosphate in lithium-treated rats. Biochem. Biophys. Res. Commun. 71, 664–670.
  Article PubMed CAS Google Scholar
• Allison J. H. and Stewart M. A. (1971) Reduced brain inositol in lithium-treated rats. Nat. New Biol. 233, 267,268.
  Article PubMed CAS Google Scholar
• Hallcher L. M. and Sherman W. R. (1980) The effects of lithium ion and other agents on the activity of myo- inositol-1-phosphatase from bovine brain. J. Biol. Chem. 255, 10,896–10,901.
  CAS Google Scholar
• Naccarato W. F., Ray R. E., and Wells W. W. (1974) Biosynthesis of myo-inositol in rat mammary gland. Isolation and properties of the enzymes. Arch. Biochem. Biophys. 164, 194–201.
  Article PubMed CAS Google Scholar
• Berridge M. J., Downes C. P., and Hanley M. R. (1982) Lithium amplifies agonist-dependent phosphatidylinositol responses in brain and salivary glands. Biochem. J. 206, 587–595.
  PubMed CAS Google Scholar
• Manji H. K. and Lenox R. H. (1999) Ziskind-Somerfeld Research Award. Protein kinase C signaling in the brain: molecular transduction of mood stabilization in the treatment of manic-depressive illness. Biol. Psychiatry 46, 1328–1351.
  Article PubMed CAS Google Scholar
• Manji H. K., Bersudsky Y., Chen G., Belmaker R. H., and Potter W. Z. (1996) Modulation of protein kinase C isozymes and substrates by lithium: the role of myo-inositol. Neuropsychopharmacology 15, 370–381.
  Article PubMed CAS Google Scholar
• Manji H. K., Etcheberrigaray R., Chen G., and Olds J. L. (1993) Lithium decreases membrane-associated protein kinase C in hippocampus: selectivity for the alpha isozyme. J. Neurochem. 61, 2303–2310.
  Article PubMed CAS Google Scholar
• Leli U. and Hauser G. (1992) Lithium modifies diacylglycerol levels and protein kinase C in neuroblastoma cells. Abstracts of the 8th international conference on second messengers and phosphoproteins, Z187F.
• Li X. and Jope R. S. (1995) Selective inhibition of the expression of signal transduction proteins by lithium in nerve growth factor-differentiated PC12 cells. J. Neurochem. 65, 2500–2508.
  Article PubMed CAS Google Scholar
• Lenox R. H., Watson D. G., Patel J., and Ellis J. (1992) Chronic lithium administration alters a prominent PKC substrate in rat hippocampus. Brain. Res. 570, 333–340.
  Article PubMed CAS Google Scholar
• Watson D. G. and Lenox R. H. (1996) Chronic lithium-induced down-regulation of MARCKS in immortalized hippocampal cells: potentiation by muscarinic receptor activation. J. Neurochem. 67, 767–777.
  Article PubMed CAS Google Scholar
• Watson D. G., Watterson J. M., and Lenox R. H. (1998) Sodium valproate down-regulates the myristoylated alanine-rich C kinase substrate (MARCKS) in immortalized hippocampal cells: a property of protein kinase C-mediated mood stabilizers. J. Pharmacol. Exp. Ther. 285, 307–316.
  PubMed CAS Google Scholar
• Fibiger H. C. (1995) Neurobiology of depression: focus on dopamine. Adv. Biochem. Psychopharmacol. 49, 1–17.
  PubMed CAS Google Scholar
• Goodwin F. K. and Jamison K. R. (1990) Manic-Depressive Illness. New York: Oxford University Press.
  Google Scholar
• Einat H., Yuan P., Gould T. D., et al. (2003) The role of the extracellular signal-regulated kinase signaling pathway in mood modulation. J. Neurosci. 23, 7311–7316.
  PubMed CAS Google Scholar
• Nestler E. J., Gould E., Manji H., et al. (2002) Preclinical models: status of basic research in depression. Biol. Psychiatry 52, 503–528.
  Article PubMed Google Scholar
• Giambalvo C. T. (1992) Protein kinase C and dopamine transport—2. Effects of amphetamine in vitro. Neuropharmacology 31, 1211–1222.
  Article PubMed CAS Google Scholar
• Gnegy M. E., Hong P., and Ferrell S. T. (1993) Phosphorylation of neuromodulin in rat striatum after acute and repeated, intermittent amphetamine. Brain. Res. Mol. Brain Res. 20, 289–298.
  Article PubMed CAS Google Scholar
• Iwata S., Hewlett G. H., and Gnegy M. E. (1997) Amphetamine increases the phosphorylation of neuromodulin and synapsin I in rat striatal synaptosomes. Synapse 26, 281–291.
  Article PubMed CAS Google Scholar
• Iwata S. I., Hewlett G. H., Ferrell S. T., Kantor L., and Gnegy M. E. (1997) Enhanced dopamine release and phosphorylation of synapsin I and neuromodulin in striatal synaptosomes after repeated amphetamine. J. Pharmacol. Exp. Ther. 283, 1445–1452.
  PubMed CAS Google Scholar
• Birnbaum S. G., Yuan P. X., Wang M., et al. (2004) Protein kinase C overactivity impairs prefrontal cortical regulation of working memory. Science 306, 882–884.
  Article PubMed CAS Google Scholar
• Moore G. J., Bebchuk J. M., Parrish J. K., et al. (1999) Temporal dissociation between lithium-induced changes in frontal lobe myo-inositol and clinical response in manic-depressive illness. Am. J. Psychiatry 156, 1902–1908.
  PubMed CAS Google Scholar
• Hahn C. G. and Friedman E. (1999) Abnormalities in protein kinase C signaling and the pathophysiology of bipolar disorder. Bipolar Disord. 1, 81–86.
  Article PubMed CAS Google Scholar
• Friedman E., Hoau Yan W., Levinson D., Connell T. A., and Singh H. (1993) Altered platelet protein kinase C activity in bipolar affective disorder, manic episode. Biol. Psychiatry 33, 520–525.
  Article PubMed CAS Google Scholar
• Wang H. Y. and Friedman E. (1996) Enhanced protein kinase C activity and translocation in bipolar affective disorder brains. Biol. Psychiatry 40, 568–575.
  Article PubMed CAS Google Scholar
• Kao K. R., Masui Y., and Elinson R. P. (1986) Lithium-induced respecification of pattern in Xenopus-laevis embryos. Nature 322, 371–373.
  Article CAS PubMed Google Scholar
• He X., Saint-Jeannet J. P., Woodgett J. R., Varmus H. E., and Dawid I. B. (1995) Glycogen synthase kinase-3 and dorsoventral patterning in Xenopus embryos. Nature 374, 617–622.
  Article PubMed CAS Google Scholar
• Klein P. S. and Melton D. A. (1996) A molecular mechanism for the effect of lithium on development. Proc. Natl. Acad. Sci. USA 93, 8455–8459.
  Article PubMed CAS Google Scholar
• Stambolic C., Ruel L., and Woodgett J. R. (1996) Lithium inhibits glycogen synthase kinase-3 activity and mimics wingless signalling in intact cells. Curr. Biol. 6, 1664–1668.
  Article PubMed CAS Google Scholar
• Gurvich N. and Klein P. S. (2002) Lithium and valproic acid: parallels and contrasts in diverse signaling contexts. Pharmacol. Ther. 96, 45–66.
  Article PubMed CAS Google Scholar
• O’Brien W. T., Harper A. D., Jove F., et al. (2004) Glycogen synthase kinase-3beta haploinsufficiency mimics the behavioral and molecular effects of lithium. J. Neurosci. 24, 6791–6798.
  Article PubMed CAS Google Scholar
• Phiel C. J., Wilson C. A., Lee V. M., and Klein P. S. (2003) GSK-3alpha regulates production of Alzheimer’s disease amyloid-beta peptides. Nature 423, 435–439.
  Article PubMed CAS Google Scholar
• Chalecka-Franaszek E. and Chuang D. M. (1999) Lithium activates the serine/threonine kinase Akt-1 and suppresses glutamate-induced inhibition of Akt-1 activity in neurons. Proc. Natl. Acad. Sci. USA 96, 8745–8750.
  Article PubMed CAS Google Scholar
• Zhang F., Phiel C. J., Spece L., Gurvich N., and Klein P. S. (2003) Inhibitory phosphorylation of glycogen synthase kinase-3 (GSK-3) in response to lithium. Evidence for autoregulation of GSK-3. J. Biol. Chem. 278, 33,067–33,077.
  CAS Google Scholar
• Kirshenboim N., Plotkin B., Shlomo S. B., Kaidanovich-Beilin O., and Eldar-Finkelman H. (2004) Lithium-mediated phosphorylation of glycogen synthase kinase-3b involves PI3 kinase-dependent activation of protein kinase C-alpha. J. Mol. Neurosci. 24, 237–245.
  Article PubMed CAS Google Scholar
• Frame S. and Cohen P. (2001) GSK3 takes centre stage more than 20 years after its discovery. Biochem. J. 359, 1–16.
  Article PubMed CAS Google Scholar
• Gould T. D., Zarate C. A. J., and Manji H. K. Glycogen synthase kinase-3: a target for novel bipolar disorder treatments. J. Clin. Psychiatry, in press.
• Woodgett J. R. (2001) Judging a protein by more than its name: gsk-3. STKE 2001, RE12.
• Gould T. D and Manji H. K. (2002) The wnt signaling pathway in bipolar disorder. Neuroscientist 8, 497–511.
  PubMed CAS Google Scholar
• Lenox R. H., Gould T. D., and Manji H. K. (2002) Endophenotypes in bipolar disorder. Am. J. Med. Genet. 114, 391–406.
  Article PubMed Google Scholar
• Jope R. S. and Bijur G. N. (2002) Mood stabilizers, glycogen synthase kinase-3beta and cell survival. Mol. Psychiatry 7(Suppl 1), S35-S45.
  Article PubMed CAS Google Scholar
• Manji H. K., Moore G. J., and Chen G. (1999) Lithium at 50: have the neuroprotective effects of this unique cation been overlooked? Biol. Psychiatry 46, 929–940.
  Article PubMed CAS Google Scholar
• Kaidanovich-Beilin O., Milman A., Weizman A., Pick C. G., and Eldar-Finkelman H. (2004) Rapid antidepressive-like activity of specific glycogen synthase kinase-3 inhibitor and its effect on beta-catenin in mouse hippocampus. Biol. Psychiatry 55, 781–784.
  Article PubMed CAS Google Scholar
• Gould T. D., Einat H., Bhat R., and Manji H. K. (2004) AR-A014418, a selective GSK-3 inhibitor, produces antidepressant-like effects in the forced swim test. Int. J. Neuropsychopharmacol. 1–4.
• Li X., Zhu W., Roh M. S., Friedman A. B., Rosborough K., and Jope R. S. (2004) In vivo regulation of glycogen synthase kinase-3beta (GSK3beta) by serotonergic activity in mouse brain. Neuropsychopharmacology 29, 1426–1431.
  Article PubMed CAS Google Scholar
• Beaulieu J. M., Sotnikova T. D., Yao W. D., et al. (2004) Lithium antagonizes dopamine-dependent behaviors mediated by an AKT/glycogen synthase kinase 3 signaling cascade. Proc. Natl. Acad. Sci. USA 101, 5099–5104.
  Article PubMed CAS Google Scholar
• Phiel C. J. and Klein P. S. (2001) Molecular targets of lithium action. Annu. Rev. Pharmacol. Toxicol. 41, 789–813.
  Article PubMed CAS Google Scholar
• Phiel C. J., Zhang F., Huang E. Y., Guenther M. G., Lazar M. A., and Klein P. S. (2001) Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen. J. Biol. Chem. 276, 36,734–36,741.
  CAS Google Scholar
• Chen G., Huang L. D., Jiang Y. M., and Manji H. K. (1999) The mood-stabilizing agent valproate inhibits the activity of glycogen synthase kinase-3. J. Neurochem. 72, 1327–1330.
  Article PubMed CAS Google Scholar
• Hall A. C., Brennan A., Goold R. G., et al. (2002) Valproate Regulates GSK-3-Mediated Axonal Remodeling and Synapsin I Clustering in Developing Neurons. Mol. Cell Neurosci. 20, 257–270.
  Article PubMed CAS Google Scholar
• Li X., Bijur G. N., and Jope R. S. (2002) Glycogen synthase kinase 3-beta, mood stabilizers, and neuroprotection. Bipolar Disorders 4, 137–144.
  Article PubMed CAS Google Scholar
• Grimes A. C. and Jope R. S. (2001) CREB DNA binding activity is inhibited by glycogen synthase kinase-3beta and facilitated by lithium. J. Neurochem. 78, 1–15.
  Article Google Scholar
• Sheline Y. I. (2003) Neuroimaging studies of mood disorder effects on the brain. Biol. Psychiatry 54, 338–352.
  Article PubMed Google Scholar
• Drevets W. C. (2000) Functional anatomical abnormalities in limbic and prefrontal cortical structures in major depression. Prog. Brain. Res. 126, 413–431.
  Article PubMed CAS Google Scholar
• Manji H. K., Drevets W. C., and Charney D. S. (2001) The cellular neurobiology of depression. Nat. Med. 7, 541–547.
  Article PubMed CAS Google Scholar
• Drevets W. C. (2003) Neuroimaging abnormalities in the amygdala in mood disorders. Ann. N. Y. Acad. Sci. 985, 420–444.
  Article PubMed Google Scholar
• Manji H. K. and Duman R. S. (2001) Impairments of neuroplasticity and cellular resilience in severe mood disorders: implications for the development of novel therapeutics. Psychopharmacol. Bull. 35, 5–49.
  PubMed CAS Google Scholar
• Drevets W. C. (2001) Neuroimaging and neuropathological studies of depression: implications for the cognitive-emotional features of mood disorders. Curr. Opin. Neurobiol. 11, 240–249.
  Article PubMed CAS Google Scholar
• Strakowski S. M., Adler C. M., and DelBello M. P. (2002) tric MRI studies of mood disorders: do they distinguish unipolar and bipolar disorder? Bipolar Disord. 4, 80–88.
  Article PubMed Google Scholar
• Beyer J. L. and Krishnan K. R. (2002) tric brain imaging findings in mood disorders. Bipolar Disorders 4, 89–104.
  Article PubMed Google Scholar
• Cotter D., Mackay D., Landau S., Kerwin R., and Everall I. (2001) Reduced glial cell density and neuronal size in the anterior cingulate cortex in major depressive disorder. Arch. Gen. Psychiatry 58, 545–553.
  Article PubMed CAS Google Scholar
• Rajkowska G. (2002) Cell pathology in bipolar disorder. Bipolar Disord 4, 129–116.
  Article Google Scholar
• Soares J. C. and Mann J. J. (1997) The anatomy of mood disorders—review of structural neuroimaging studies. Biol. Psychiatry 41, 86–106.
  Article PubMed CAS Google Scholar
• Stoll A. L., Renshaw P. F., Yurgelun-Todd D. A., and Cohen B. M. (2000) Neuroimaging in bipolar disorder: what have we learned? Biol. Psychiatry 48, 505–517.
  Article PubMed CAS Google Scholar
• Kessler R. C. (1997) The effects of stressful life events on depression. Annu. Rev. Psychol. 48, 191–214.
  Article PubMed CAS Google Scholar
• McEwen B. S. (1999) Stress and hippocampal plasticity. Annu. Rev. Neurosci. 22, 105–122.
  Article PubMed CAS Google Scholar
• Lee A. L., Ogle W. O., and Sapolsky R. M. (2002) Stress and depression: possible links to neuron death in the hippocampus. Bipolar Disorders 4, 117–128.
  Article PubMed CAS Google Scholar
• Sapolsky R. M. (2001) Depression, antidepressants, and the shrinking hippocampus. Proc. Natl. Acad. Sci. USA 98, 12,320–12,322.
  Article CAS Google Scholar
• Sapolsky R. M. (2000) Glucocorticoids and hippocampal atrophy in neuropsychiatric disorders. Arch. Gen. Psychiatry 57, 925–935.
  Article PubMed CAS Google Scholar
• Malberg J. E. and Duman R. S. (2003) Cell proliferation in adult hippocampus is decreased by inescapable stress: reversal by fluoxetine treatment. Neuropsychopharmacology 28, 1562–1571.
  Article PubMed CAS Google Scholar
• Pham K., Nacher J., Hof P. R., and McEwen B. S. (2003) Repeated restraint stress suppresses neurogenesis and induces biphasic PSA-NCAM expression in the adult rat dentate gyrus. Eur. J. Neurosci. 17, 879–886.
  Article PubMed Google Scholar
• Gould E., Tanapat P., Rydel T., and Hastings N. (2000) Regulation of hippocampal neurogenesis in adulthood. Biol. Psychiatry 48, 715–720.
  Article PubMed CAS Google Scholar
• Bhat R. V., Shanley J., Correll M. P., et al. (2000) Regulation and localization of tyrosine216 phosphorylation of glycogen synthase kinase-3beta in cellular and animal models of neuronal degeneration. Proc. Natl. Acad. Sci. USA 97, 11,074–11,079.
  Article CAS Google Scholar
• Cimarosti H., Rodnight R., Tavares A., et al. (2001) An investigation of the neuroprotective effect of lithium in organotypic slice cultures of rat hippocampus exposed to oxygen and glucose deprivation. Neurosci. Lett. 315, 33–36.
  Article PubMed CAS Google Scholar
• D’Mello S. R., Anelli R., and Calissano P. (1994) Lithium induces apoptosis in immature cerebellar granule cells but promotes survival of mature neurons. Exp. Cell. Res. 211, 332–338.
  Article PubMed CAS Google Scholar
• Khodorov B., Pinelis V., Vinskaya N., Sorokina E., Grigortsevich N., and Storozhevykh T. (1999) Li+ protects nerve cells against destabilization of Ca2+ homeostasis and delayed death caused by removal of external Na+. FEBS Lett. 448, 173–176.
  Article PubMed CAS Google Scholar
• Nonaka S., Hough C. J., and Chuang D. M. (1998) Chronic lithium treatment robustyl protects neurons in the central nervous system against excitotoxicity by inhibiting N-methyl-D-aspartate receptor-mediated calcium influx. Proc. Natl. Acad. Sci. USA 95, 2642–2647.
  Article PubMed CAS Google Scholar
• Hashimoto R., Hough C., Nakazawa T., Yamamoto T., and Chuang D. M. (2002) Lithium protection against glutamate excitotoxicity in rat cerebral cortical neurons: involvement of NMDA receptor inhibition possibly by decreasing NR2B tyrosine phosphorylation. J. Neurochem. 80, 589–597.
  Article PubMed CAS Google Scholar
• Kanai H., Chalecka-Franaszek E., Chen R. W., Hashimoto R., Hiroi T., and Chuang D. M. (2001) Valproic acid protects against glutamate-induced excitotoxicity in mature cerebellar granule cells. Society for Neuroscience Annual Meeting Abstract 94.18.
• Chen R. W. and Chuang D. M. (1999) Long term lithium treatment suppresses p53 and Bax expression but increases Bcl-2 expression. A prominent role in neuroprotection against excitotoxicity. J. Biol. Chem. 274, 6039–6042.
  Article PubMed CAS Google Scholar
• Centeno F., Mora A., Fuentes J. M., Soler G., and Claro E. (1998) Partial lithium-associated protection against apoptosis induced by C2-ceramide in cerebellar granule neurons. Neuroreport 9, 4199–4203.
  Article PubMed CAS Google Scholar
• Nonaka S., Katsube N., and Chuang D. M. (1998) Lithium protects rat cerebellar granule cells against apoptosis induced by anticonvulsants, phenytoin and carbamazepine. J. Pharmacol. Exp. Ther. 286, 539–547.
  PubMed CAS Google Scholar
• Jeong M. R., Hashimoto R., Senatorov V. V., et al. (2003) Valproic acid, a mood stabilizer and anticonvulsant, protects rat cerebral cortical neurons from spontaneous cell death: a role of histone deacetylase inhibition. FEBS Lett. 542, 74–78.
  Article PubMed CAS Google Scholar
• Alvarez G., Munoz-Montano J. R., Satrustegui J., Avila J., Bogonez E., and Diaz-Nido J. (1999) Lithium protects cultured neurons against beta-amyloid-induced neurodegeneration. FEBS Lett. 453, 260–264.
  Article PubMed CAS Google Scholar
• Chuang D. M., Chen R., Chalecka-Franaszek E., et al. (2002) Neuroprotective effects of lithium in cultured cells and animal models of diseases. Bipolar Disorders 4, 129–136.
  Article PubMed CAS Google Scholar
• Chen G., Zeng W. Z., Yuan P. X., et al. (1999) The mood-stabilizing agents lithium and valproate robustly increase the levels of the neuroprotective protein bcl-2 in the CNS. J. Neurochem. 72, 879–882.
  Article PubMed CAS Google Scholar
• Nonaka S. and Chuang D. M. (1998) Neuroprotective effects of chronic lithium on focal cerebral ischemia in rats. Neuroreport 9, 2081–2084.
  Article PubMed CAS Google Scholar
• Ren M., Senatorov V. V., Chen R. W., and Chuang D. M. (2003) Postinsult treatment with lithium reduces brain damage and facilitates neurological recovery in a rat ischemia/reperfusion model. Proc. Natl. Acad. Sci. USA 100, 6210–6215.
  Article PubMed CAS Google Scholar
• Ren M., Leng Y., Jeong M. R., Leeds P., and Chuang D. M. (2004) Valproaic acid reduces brain damage induced by transient focal cerebral ischemia in rats: potential roles of histone deacetylase inhibition and heat shock protein induction. J. Neurochem. 89, 1358–1367.
  Article PubMed CAS Google Scholar
• Wei H., Qin Z. H., Senatorov V. V., et al. (2001) Lithium suppresses excitotoxicity-induced striatal lesions in a rat model of Huntington’s disease. Neuroscience 106, 603–612.
  Article PubMed CAS Google Scholar
• Cameron H. A., Hazel T. G., and McKay R. D. (1998) Regulation of neurogenesis by growth factors and neurotransmitters. J. Neurobiol. 36, 287–306.
  Article PubMed CAS Google Scholar
• Gage F. H. (2000) Mammalian neural stem cells. Science 287, 1433–1438.
  Article PubMed CAS Google Scholar
• Jacobs B. L. (2002) Adult brain neurogenesis and depression. Brain. Behav. Immun. 16, 602–609.
  Article PubMed CAS Google Scholar
• Jacobs B. L., Praag H., and Gage F. H. (2000) Adult brain neurogenesis and psychiatry: a novel theory of depression. Mol. Psychiatry 5, 262–269.
  Article PubMed CAS Google Scholar
• Magavi S. S. and Macklis J. D. (2001) Manipulation of neural precursors in situ: induction of neurogenesis in the neocortex of adult mice. Neuropsychopharmacology 25, 816–835.
  Article PubMed CAS Google Scholar
• Duman R. S., Nakagawa S., and Malberg J. (2001) Regulation of adult neurogenesis by antidepressant treatment. Neuropsychopharmacology 25, 836–844.
  Article PubMed CAS Google Scholar
• Malberg J. E., Eisch A. J., Nestler E. J., and Duman R. S. (2000) Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus. J. Neurosci. 20, 9104–9110.
  PubMed CAS Google Scholar
• Manev H., Uz T., Smalheiser N. R., and Manev R. (2001) Antidepressants alter cell proliferation in the adult brain in vivo and in neural cultures in vitro. Eur. J. Pharmacol. 411, 67–70.
  Article PubMed CAS Google Scholar
• Santarelli L., Saxe M., Gross C., et al. (2003) Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants. Science 301, 805–809.
  Article PubMed CAS Google Scholar
• Hashimoto R., Senatorov V., Kanai H., Leeds P., and Chuang D. M. (2003) Lithium stimulates progenitor proliferation in cultured brain neurons. Neuroscience 117, 55–61.
  Article PubMed CAS Google Scholar
• Chen G., Rajkowska G., Du F., Seraji-Bozorgzad N., and Manji H. K. (2000) Enhancement of hippocampal neurogenesis by lithium. J. Neurochem. 75, 1729–1734.
  Article PubMed CAS Google Scholar
• Hao Y., Creson T., Zhang L., et al. (2004) Mood stabilizer valproate promotes ERK pathway-dependent cortical neuronal growth and neurogenesis. J. Neurosci. 24, 6590–6599.
  Article PubMed CAS Google Scholar
• McAllister A. K. (2002) Neurotrophins and cortical development. Results Probl. Cell. Differ. 39, 89–112.
  PubMed CAS Google Scholar
• McAllister A. K., Katz L. C., and Lo D. C. (1999) Neurotrophins and synaptic plasticity. Annu. Rev. Neurosci. 22, 295–318.
  Article PubMed CAS Google Scholar
• McAllister A. K. (2001) Neurotrophins and neuronal differentiation in the central nervous system. Cell. Mol. Life Sci. 58, 1054–1060.
  Article PubMed CAS Google Scholar
• Rasmusson A. M., Shi L., and Duman R. (2002) Downregulation of BDNF mRNA in the hippocampal dentate gyrus after re-exposure to cues previously associated with footshock. Neuropsychopharmacology 27, 133–142.
  Article PubMed CAS Google Scholar
• Smith M. A. and Cizza G. (1996) Stress-induced changes in brain-derived neurotrophic factor expression are attenuated in aged Fischer 344/N rats. Neurobiol. Aging 17, 859–864.
  Article PubMed CAS Google Scholar
• Ueyama T., Kawai Y., Nemoto K., Sekimoto M., Tone S., and Senba E. (1997) Immobilization stress reduced the expression of neurotrophins and their receptors in the rat brain. Neurosci. Res. 28, 103–110.
  Article PubMed CAS Google Scholar
• Smith M. A., Makino S., Kvetnansky R., and Post R. M. (1995) Effects of stress on neurotrophic factor expression in the rat brain. Ann. NY Acad. Sci. 771, 234–239.
  Article PubMed CAS Google Scholar
• Nibuya M., Morinobu S., and Duman R. S. (1995) Regulation of BDNF and trkB mRNA in rat brain by chronic electroconvulsive seizure and antidepressant drug treatments. J. Neurosci. 15, 7539–7547.
  PubMed CAS Google Scholar
• Chen B., Dowlatshahi D., MacQueen G. M., Wang J. F., and Young L. T. (2001) Increased hippocampal BDNF immunoreactivity in subjects treated with antidepressant medication. Biol. Psychiatry 50, 260–265.
  Article PubMed CAS Google Scholar
• Shirayama Y., Chen A. C., Nakagawa S., Russell D. S., and Duman R. S. (2002) Brain-derived neurotrophic factor produces antidepressant effects in behavioral models of depression. J. Neurosci. 22, 3251–3261.
  PubMed CAS Google Scholar
• Fukumoto T., Morinobu S., Okamoto Y., Kagaya A., and Yamawaki S. (2001) Chronic lithium treatment increases the expression of brain-derived neurotrophic factor in the rat brain. Psychopharmacology (Berl) 158, 100–106.
  Article CAS Google Scholar
• Hashimoto R., Takei N., Shimazu K., Christ L., Lu B., and Chuang D. M. (2002) Lithium induces brain-derived neurotrophic factor and activates TrkB in rodent cortical neurons: an essential step for neuroprotection against glutamate excitotoxicity. Neuropharmacology 43, 1173–1179.
  Article PubMed CAS Google Scholar
• Yu I. T., Kim J. S., Lee S. H., Lee Y. S., and Son H. (2003) Chronic lithium enhances hippocampal long-term potentiation, but not neurogenesis, in the aged rat dentate gyrus. Biochem. Biophys. Res. Commun. 303, 1193–1198.
  Article PubMed CAS Google Scholar
• Son H., Yu I. T., Hwang S. J., et al. (2003) Lithium enhances long-term potentiation independently of hippocampal neurogenesis in the rat dentate gyrus. J. Neurochem. 85, 872–881.
  Article PubMed CAS Google Scholar
• Schlessinger J. (2000) Cell signaling by receptor tyrosine kinases. Cell 103, 211–225.
  Article PubMed CAS Google Scholar
• Poo M. M. (2001) Neurotrophins as synaptic modulators. Nat. Rev. Neurosci. 2, 24–32.
  Article PubMed CAS Google Scholar
• Patapoutian A. and Reichardt L. F. (2001) Trk receptors: mediators of neurotrophin action. Curr. Opin. Neurobiol. 11, 272–280.
  Article PubMed CAS Google Scholar
• Yuan P. X., Huang L. D., Jiang Y. M., Gutkind J. S., Manji H. K., and Chen G. (2001) The mood stabilizer valproic acid activates mitogen-activated protein kinases and promotes neurite growth. J. Biol. Chem. 276, 31,674–31,683.
  CAS Google Scholar
• Manji H. K., Moore G. J., Rajkowska G., and Chen G. (2000) Neuroplasticity and cellular resilience in mood disorders. Mol. Psychiatry 5, 578–593.
  Article PubMed CAS Google Scholar
• Huang X., Wu D. Y., Chen G., Manji H., and Chen D. F. (2003) Support of retinal ganglion cell survival and axon regeneration by lithium through a Bcl-2-dependent mechanism. Invest. Ophthalmol. Vis. Sci. 44, 347–354.
  Article PubMed Google Scholar
• Quiroz J., Singh J., Gould T. D., Denicoff K. D., Zarate C. A., and Manji H. K. (2004) Emerging experimental therapeutics for bipolar disorder: clues from the molecular pathophysiology. Mol. Psychiatry. 9, 734–755.
  Article PubMed CAS Google Scholar
• De Sarno P., Li X., and Jope R. S. (2002) Regulation of Akt and glycogen synthase kinase-3beta phosphorylation by sodium valproate and lithium. Neuropharmacology 43, 1158–1164.
  Article PubMed Google Scholar
• Kato T. and Kato N. (2000) Mitochondrial dysfunction in bipolar disorder. Bipolar Disord. 2, 180–190.
  Article PubMed CAS Google Scholar
• Tseng W. P. and Lin-Shiau S. Y. (2002) Long-term lithium treatment prevents neurotoxic effects of beta-bungarotoxin in primary cultured neurons. J. Neurosci. Res. 69, 633–641.
  Article PubMed CAS Google Scholar
• Wang J. F., Azzam J. E., and Young L. T. (2003) Valproate inhibits oxidative damage to lipid and protein in primary cultured rat cerebrocortical cells. Neuroscience 116, 485–489.
  Article PubMed CAS Google Scholar
• Pivovarova N. B., Pozzo-Miller L. D., Hongpaisan J., and Andrews S. B. (2002) Correlated calcium uptake and release by mitochondria and endoplasmic reticulum of CA3 hippocampal dendrites after afferent synaptic stimulation. J. Neurosci. 22, 10,653–10,661.
  CAS Google Scholar
• Williams J. M., Thompson V. L., Mason-Parker S. E., Abraham W. C., and Tate W. P. (1998) Synaptic activity-dependent modulation of mitochondrial gene expression in the rat hippocampus. Brain. Res. Mol. Brain Res. 60, 50–56.
  Article PubMed CAS Google Scholar
• Mattson M. P. and Liu D. (2003) Mitochondrial potassium channels and uncoupling proteins in synaptic plasticity and neuronal cell death. Biochem. Biophys. Res. Commun. 304, 539–549.
  Article PubMed CAS Google Scholar
• Murphy A. N., Bredesen D. E., Cortopassi G., Wang E., and Fiskum G. (1996) Bcl-2 potentiates the maximal calcium uptake capacity of neural cell mitochondria. Proc. Natl. Acad. Sci. USA 93, 9893–9898.
  Article PubMed CAS Google Scholar
• Duchen M. R. (2000) Mitochondria and Ca(2+)in cell physiology and pathophysiology. Cell Calcium 28, 339–348.
  Article PubMed CAS Google Scholar
• Hoshi M., Sato M., Kondo S., et al. (1995) Different localization of tau protein kinase I/glycogen synthase kinase-3 beta from glycogen synthase kinase-3 alpha in cerebellum mitochondria. J. Biochem. (Tokyo) 118, 683–685.
  CAS Google Scholar
• King T. D., Bijur G. N., and Jope R. S. (2001) Caspase-3 activation induced by inhibition of mitochondrial complex I is facilitated by glycogen synthase kinase-3beta and attenuated by lithium. Brain. Res. 919, 106–114.
  Article PubMed CAS Google Scholar
• Dumont P., Leu J. I., Della Pietra A. C. 3rd, George D. L., and Murphy M. (2003) The codon 72 polymorphic variants of p53 have markedly different apoptotic potential. Nat. Genet. 33, 357–365.
  Article PubMed CAS Google Scholar
• Marchenko N. D., Zaika A., and Moll U. M. (2000) Death signal-induced localization of p53 protein to mitochondria. A potential role in apoptotic signaling. J. Biol. Chem. 275, 16,202–16,212.
  Article CAS Google Scholar
• Sansome C., Zaika A., Marchenko N. D., and Moll U. M. (2001) Hypoxia death stimulus induces translocation of p53 protein to mitochondria. Detection by immunofluorescence on whole cells. FEBS Lett. 488, 110–115.
  Article PubMed CAS Google Scholar
• Watcharasit P., Bijur G. N., Song L., Zhu J., Chen X., and Jope R. S. (2003) Glycogen synthase kinase-3beta (GSK3beta) binds to and promotes the actions of p53. J. Biol. Chem. 278, 48,872–48,879.
  Article CAS Google Scholar
• Bijur G. N. and Jope R. S. (2003) Rapid accumulation of Akt in mitochondria following phosphatidylinositol 3-kinase activation. J. Neurochem. 87, 1427–1435.
  Article PubMed CAS Google Scholar
• Linseman D. A., Butts B. D., Precht T. A., et al. (2004) Glycogen synthase kinase-3beta phosphorylates Bax and promotes its mitochondrial localization during neuronal apoptosis. J. Neurosci. 24, 9993–10,002.
  Article PubMed CAS Google Scholar
• Moore G. J., Bebchuk J. M., Hasanat K., et al. (2000) Lithium increases N-acetyl-aspartate in the human brain: in vivo evidence in support of bcl-2’s neurotrophic effects? Biol. Psychiatry 48, 1–8.
  Article PubMed CAS Google Scholar
• Moore G. J., Bebchuk J. M., Wilds I. B., Chen G., and Manji H. K. (2000) Lithium-induced increase in human brain grey matter. Lancet 356, 1241,1242.
  Article PubMed CAS Google Scholar
• Silverstone P. H., Wu R. H., O’Donnell T., Ulrich M., Asghar S. J., and Hanstock C. C. (2003) Chronic treatment with lithium, but not sodium valproate, increases cortical _N_-acetylaspartate concentrations in euthymic bipolar patients. Int. Clin. Psychopharmacol. 18, 73–79.
  Article PubMed Google Scholar
• Sassi R., Nicoletti M., Brambilla P., et al. (2002) Increased gray matter in lithium-treated bipolar disorder patients. Neurosci. Lett. 329, 243.
  Article PubMed CAS Google Scholar
• Atack J. R. (1997) Inositol monophosphatase inhibitors—lithium mimetics? Med. Res. Rev. 17, 215–224.
  Article PubMed CAS Google Scholar
• Atack J. R., Cook S. M., Watt A. P., Fletcher S. R., and Ragan C. I. (1993) In vitro and in vivo inhibition of inositol monophosphatase by the bisphosphonate L-690,330. J. Neurochem. 60, 652–658.
  Article PubMed CAS Google Scholar
• Atack J. R., Prior A. M., Fletcher S. R., Quirk K., McKernan R., and Ragan C. I. (1994) Effects of L-690,488, a prodrug of the bisphosphonate inositol monophosphatase inhibitor L-690,330, on phosphatidylinositol cycle markers. J. Pharmacol. Exp. Ther. 270, 70–76.
  PubMed CAS Google Scholar
• Pollack S. J., Atack J. R., Knowles M. R., et al. (1994) Mechanism of inositol monophosphatase, the putative target of lithium therapy. Proc. Natl. Acad. Sci. USA 91, 5766–5770.
  Article PubMed CAS Google Scholar
• Bone R., Springer J. P., and Atack J. R. (1992) Structure of inositol monophosphatase, the putative target of lithium therapy. Proc. Natl. Acad. Sci. USA 89, 10,031–10,035.
  Article CAS Google Scholar
• Chen S. J., Sweatt J. D., and Klann E. (1997) Enhanced phosphorylation of the postsynaptic protein kinase C substrate RC3/neurogranin during long-term potentiation. Brain. Res. 749, 181–187.
  Article PubMed CAS Google Scholar
• Conn P. J. and Sweatt J. D. (1994) Protein kinase C in the nervous system. In: Protein Kinase C, Kuo J. F., ed. New York: Oxford University Press, pp. 199–235.
  Google Scholar
• Manji H. K. and Chen G. (2002) PKC, MAP kinases and the bcl-2 family of proteins as long-term targets for mood stabilizers. Mol. Psychiatry 7 (Suppl 1), S46-S56.
  Article PubMed CAS Google Scholar
• Bebchuk J. M., Arfken C. L., Dolan-Manji S., Murphy J., Hasanat K., and Manji H. K. (2000) A preliminary investigation of a protein kinase C inhibitor in the treatment of acute mania. Arch. Gen. Psychiatry 57, 95–97.
  Article PubMed CAS Google Scholar
• Horgan K., Cooke E., Hallett M. B., and Mansel R. E. (1986) Inhibition of protein kinase C mediated signal transduction by tamoxifen. Importance for antitumour activity. Biochem. Pharmacol. 35, 4463–4465.
  Article PubMed CAS Google Scholar
• O’Brian C. A., Housey G. M., and Weinstein I. B. (1988) Specific and direct binding of protein kinase C to an immobilized tamoxifen analogue. Cancer Res. 48, 3626–3629.
  PubMed CAS Google Scholar
• Frank R. N. (2002) Potential new medical therapies for diabetic retinopathy: protein kinase C inhibitors. Am. J. Ophthalmol. 133, 693–698.
  Article PubMed CAS Google Scholar
• Wheeler G. D. (2003) Ruboxistaurin (Eli Lilly). IDrugs 6, 159–163.
  PubMed CAS Google Scholar
• Aiello L. P. (2002) The potential role of PKC beta in diabetic retinopathy and macular edema. Surv. Ophthalmol. 47 (Suppl 2), S263-S269.
  Article PubMed Google Scholar
• Parker P. J. (1999) Inhibition of protein kinase C—do we, can we, and should we? Pharmacol. Ther. 82, 263–267.
  Article PubMed CAS Google Scholar
• Kaidanovich O. and Eldar-Finkelman H. (2002) The role of glycogen synthase kinase-3 in insulin resistance and Type 2 diabetes. Expert Opin. Ther. Targets 6, 555–561.
  Article PubMed CAS Google Scholar
• Bhat R. V. and Budd S. L. (2002) GSK3beta signalling: casting a wide net in Alzheimer’s disease. Neurosignals 11, 251–261.
  Article PubMed CAS Google Scholar
• Alvarez G., Munoz-Montano J. R., Satrustegui J., Avila J., Bogonez E., and Diaz-Nido J. (2002) Regulation of tau phosphorylation and protection against beta-amyloid-induced neurodegeneration by lithium. Possible implications for Alzheimer’s disease. Bipolar Disord. 4, 153–165.
  Article PubMed CAS Google Scholar
• Sun X., Sato S., Murayama O., et al. (2002) Lithium inhibits amyloid secretion in COS7 cells transfected with amyloid precursor protein C100. Neurosci. Lett. 321, 61–64.
  Article PubMed CAS Google Scholar
• Tong H., Imahashi K., Steenbergen C., and Murphy E. (2002) Phosphorylation of glycogen synthase kinase-3beta during preconditioning through a phosphatidylinositol-3-kinase—dependent pathway is cardioprotective. Circ. Res. 90, 377–379.
  Article PubMed CAS Google Scholar
• Frame S. and Cohen P. (2001) GSK3 takes centre stage more than 20 years after its discovery. Biochem. J. 359, 1–16.
  Article PubMed CAS Google Scholar
• Sasaki C., Hayashi T., Zhang W. R., et al. (2001) Different expression of glycogen synthase kinase-3beta between young and old rat brains after transient middle cerebral artery occlusion. Neurol. Res. 23, 588–592.
  Article PubMed CAS Google Scholar
• Dorronsoro I., Castro A., and Martinez A. (2002) Inhibitors of glycogen synthase kinase-3: future therapy for unmet medical needs. Expert Opin. Ther. Patents 12, 1527–1536.
  Article CAS Google Scholar
• Martinez A., Alonso M., Castro A., Perez C., and Moreno F. J. (2002) First non-ATP competitive glycogen synthase kinase 3 beta (GSK-3beta) inhibitors: thiadiazolidinones (TDZD) as potential drugs for the treatment of Alzheimer’s disease. J. Med. Chem. 45, 1292–1299.
  Article PubMed CAS Google Scholar
• Plotkin B., Kaidanovich O., Talior I., and Eldar-Finkelman H. (2003) Insulin mimetic action of synthetic phosphorylated Peptide inhibitors of glycogen synthase kinase-3. J. Pharmacol. Exp. Ther. 305, 974–980.
  Article PubMed CAS Google Scholar
• Martinez A., Castro A., Dorronsoro I., and Alonso M. (2002) Glycogen synthase kinase 3 (GSK-3) inhibitors as new promising drugs for diabetes, neurodegeneration, cancer, and inflammation. Med. Res. Rev. 22, 373–384.
  Article PubMed CAS Google Scholar
• Cohen P. and Frame S. (2001) The renaissance of GSK3. Nat. Rev. Mol. Cell Biol. 2, 769–776.
  Article PubMed CAS Google Scholar
• Ilouz R., Kaidanovich O., Gurwitz D., and Eldar-Finkelman H. (2002) Inhibition of glycogen synthase kinase-3beta by bivalent zinc ions: insight into the insulin-mimetic action of zinc. Biochem. Biophys. Res. Commun. 295, 102–106.
  Article PubMed CAS Google Scholar
• D’Sa C. and Duman R. (2002) Antidepressants and neuroplasticity. Bipolar Disorder 4, 183.
  Article CAS Google Scholar
• Manji H. K., Quiroz J. A., Sporn J., et al. (2003) Enhancing neuronal plasticity and cellular resilience to develop novel, improved therapeutics for difficult-to-treat depression. Biol. Psychiatry 53, 707–742.
  Article PubMed CAS Google Scholar
• Zeller E., Stief H. J., Pflug B., and Sastre-y-Hernandez M. (1984) Results of a phase II study of the antidepressant effect of rolipram. Pharmacopsychiatry 17, 188–190.
  PubMed CAS Google Scholar
• Bobon D., Breulet M., Gerard-Vandenhove M. A., et al. (1988) Is phosphodiesterase inhibition a new mechanism of antidepressant action? A double blind double-dummy study between rolipram and desipramine in hospitalized major and/or endogenous depressives. Eur. Arch. Psychiatry. Neurol. Sci. 238, 2–6.
  Article PubMed CAS Google Scholar
• Hebenstreit G. F., Fellerer K., Fichte K., et al. (1989) Rolipram in major depressive disorder: results of a double-blind comparative study with imipramine. Pharmacopsychiatry 22, 156–160.
  PubMed CAS Google Scholar
• Zhu J., Mix E., and Winblad B. (2001) The antidepressant and antiinflammatory effects of rolipram in the central nervous system. CNS Drug. Rev. 7, 387–398.
  Article PubMed CAS Google Scholar
• Marks P., Rifkind R. A., Richon V. M., Breslow R., Miller T., and Kelly W. K. (2001) Histone deacetylases and cancer: causes and therapies. Nat. Rev. Cancer. 1, 194–202.
  Article PubMed CAS Google Scholar
• Ketter T. A. and Wang P. W. (2003) The emerging differential roles of GABAergic and antiglutamatergic agents in bipolar disorders. J. Clin. Psychiatry 64(Suppl 3), 15–20.
  PubMed CAS Google Scholar
• Plotsky P. M., Owens M. J., and Nemeroff C. B. (1998) Psychoneuroendocrinology of depression. Hypothalamic-pituitary-adrenal axis. Psychiatr. Clin. North. Am. 21, 293–307.
  Article PubMed CAS Google Scholar
• Gold P. W. and Chrousos G. P. (2002) Organization of the stress system and its dysregulation in melancholic and atypical depression: high vs low CRH/NE states. Mol. Psychiatry 7, 254–275.
  Article PubMed CAS Google Scholar
• Seymour P. A., Schmidt A. W., and Schulz D. W. (2003) The pharmacology of CP-154,526, a non-peptide antagonist of the CRH1 receptor: a review. CNS Drug Rev. 9, 57–96.
  Article PubMed CAS Google Scholar
• Mansbach R. S., Brooks E. N., and Chen Y. L. (1997) Antidepressant-like effects of CP-154,526, a selective CRF1 receptor antagonist. Eur. J. Pharmacol. 323, 21–26.
  Article PubMed CAS Google Scholar
• Miner J. N., Tyree C., Hu J., et al. (2003) A non-steroidal glucocorticoid receptor antagonist. Mol. Endocrinol. 17, 117–127.
  Article PubMed CAS Google Scholar
• Honer C., Nam K., Fink C., et al. (2003) Glucocorticoid receptor antagonism by cyproterone acetate and RU486. Mol. Pharmacol. 63, 1012–1020.
  Article PubMed CAS Google Scholar
• Ur E., Turner T. H., Goodwin T. J., Grossman A., and Besser G. M. (1992) Mania in association with hydrocortisone replacement for Addison’s disease. Postgrad. Med. J. 68, 41–43.
  Article PubMed CAS Google Scholar
• Salek F. S., Bigos K. L., and Kroboth P. D. (2002) The influence of hormones and pharmaceutical agents on DHEA and DHEA-S concentrations: a review of clinical studies. J. Clin. Pharmacol. 42, 247–266.
  Article PubMed CAS Google Scholar
• Zarate C. A., Quiroz J., Payne J., and Manji H. K. (2002) Modulators of the glutamatergic system: implications for the development of improved therapeutics in mood disorders. Psychopharmacol. Bull. 36, 35–83.
  PubMed Google Scholar
• Einat H., Manji H. K., and Belmater R. H. (2003) New approaches to modeling bipolar disorder. Psychopharm. Bull. 37, 47–63.
  Google Scholar