Generating Murine Osteoclasts from Bone Marrow (original) (raw)

References

  1. Roodman, G. D. (1996) Advances in bone biology: the osteoclast. Endocr. Rev. 17, 308–332.
    PubMed CAS Google Scholar
  2. Suda, T., Takahashi, N., and Martin, T. J. (1992) Modulation of osteoclast differentiation. Endocr. Rev. 13, 66–80.
    PubMed CAS Google Scholar
  3. Takahashi, N., Yamana, H., Yoshiki, S., et al. (1988) Osteoclast-like cell formation and its regulation by osteotropic hormones in mouse bone marrow cultures. Endocrinology 122, 1373–1382.
    Article PubMed CAS Google Scholar
  4. Takahashi, N., Akatsu, T., Udagawa, N., et al. (1988) Osteoblastic cells are involved in osteoclast formation. Endocrinology 123, 2600–2602.
    Article PubMed CAS Google Scholar
  5. Yoshida, H., Hayashi, S., Kunisada, T., et al. (1990) The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene. Nature 345, 442–444.
    Article PubMed CAS Google Scholar
  6. Yasuda, H,, Shima, N., Nakagawa, N., et al. (1999) A novel molecular mechanism modulating osteoclast differentiation and function. Bone 25, 109–113.
    Article PubMed CAS Google Scholar
  7. Takahashi, N., Udagawa, N., and Suda, T. (1999) A new member of TNF ligand family, ODF/RANKL/TRANCE/OPGL, regulates osteoclast differentiation and function. Biochem. Biophys. Res. Commun. 256, 449–455.
    Article PubMed CAS Google Scholar
  8. Tanaka, S., Takahashi, T., Takayanagi, H., et al. (1998) Modulation of osteoclast function by adenovirus vector-induced epidermal growth factor receptor. J. Bone Miner. Res. 13, 1714–1720.
    Article PubMed CAS Google Scholar
  9. Kobayashi, K., Takahashi, N., Jimi, E., et al. (2000) Tumor necrosis factor α stimulates osteoclast differentiation by a mechanism independent of the ODF/RANKL-RANK interaction. J. Exp. Med. 191, 275–286.
    Article PubMed CAS Google Scholar
  10. Akatsu, T., Tamura, T., Takahashi, N., et al. (1992) Preparation and characterization of a mouse multinucleated cell population. J. Bone Miner. Res. 7, 1297–1306.
    Article PubMed CAS Google Scholar
  11. Suda, T., Nakamura, I., Jimi, E., and Takahashi, N. (1997) Regulation of osteoclast function. J. Bone Miner. Res. 12, 869–879.
    Article PubMed CAS Google Scholar
  12. Jimi, E., Ikebe, T., Takahashi, N., Hirata, N., Suda, T., and Koga, T. (1996) Interleukin-1 β activates an NF-κB-like factor in osteoclast-like cells. J. Biol. Chem. 271, 4605–4608.
    Article PubMed CAS Google Scholar
  13. Suda, T., Jimi, E., Nakamura, I., and Takahashi, N. (1997) Role of 1α,25-dihydroxyvitamin D3 in osteoclast differentiation and function. Methods Enzymol. 282, 223–235.
    Article PubMed CAS Google Scholar
  14. Nakamura, I., Takahashi, N, Sasaki, T., et al. (1995) Wortmannin, a specific inhibitor of phosphatidylinositol-3 kinase, blocks osteoclastic bone resorption. FEBS Lett. 361, 79–84.
    Article PubMed CAS Google Scholar
  15. Zhang, D., Udagawa, N., Nakamura, I., et al. (1995) The small GTP-binding protein, rho p21, is involved in bone resorption by regulating cytoskeletal organization in osteoclasts. J. Cell Sci. 108, 2285–2292.
    PubMed CAS Google Scholar
  16. Tanaka, S., Takahashi, N., Udagawa, N., et al. (1992) Osteoclasts express high levels of p60c-src, preferentially on ruffled border membranes. FEBS Lett. 313 85–89.
    Article PubMed CAS Google Scholar
  17. Jimi, E., Nakamura, I., Duong, L. T., et al. (1999) Interleukin 1 induces multinucleation and bone-resorbing activity of osteoclasts in the absence of osteoblasts/stromal cells. Exp. Cell Res. 247, 84–93.
    Article PubMed CAS Google Scholar
  18. Jimi, E., Akiyama, S., Tsurukai, T., et al. (1999) Osteoclast differentiation factor acts as a multifunctional regulator in murine osteoclast differentiation and function. J. Immunol. 163, 434–442.
    PubMed CAS Google Scholar
  19. Wesolowski, G., Duong, L. T., Lakkakorpi, P. T., et al. (1995) Isolation and characterization of highly enriched, prefusion mouse osteoclastic cells. Exp. Cell Res. 219, 679–686.
    Article PubMed CAS Google Scholar
  20. Takahashi, N., Akatsu, T., Sasaki, T., et al. (1988) Induction of calcitonin receptors by 1α,25-dihydroxyvitamin D3 in osteoclast-like multinucleated cells formed from mouse bone marrow cells. Endocrinology 123, 1504–1510.
    Article PubMed CAS Google Scholar
  21. Tamura, T., Takahashi, N., Akatsu, T., et al. (1993) A new resorption assay with mouse osteoclast-like multinucleated cells formed in vitro. J. Bone Miner. Res. 8, 953–960.
    Article PubMed CAS Google Scholar
  22. Miyake, S., Makimura, M., Kanegae, Y., et al. (1996) Efficient generation of recombinant adenoviruses using adenovirus DNA-terminal protein complex and a cosmid bearing the full-length virus genome. Proc. Natl. Acad. Sci. USA 93, 1320–1324.
    Article PubMed CAS Google Scholar
  23. Simonet, W. S., Lacey, D. L., Dunstan, C. R., et al. (1997) Osteoprotegerin: a novel secreted protein involved in the regulation of bone density. Cell 89, 309–319.
    Article PubMed CAS Google Scholar
  24. Tsuda, E., Goto, M., Mochizuki, S., et al. (1997) Isolation of a novel cytokine from human fibroblasts that specifically inhibits osteoclastogenesis. Biochem. Biophys. Res. Commun. 234, 137–142.
    Article PubMed CAS Google Scholar
  25. Yasuda, H., Shima, N., Nakagawa, N., et al. (1998) Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL. Proc. Natl. Acad. Sci. USA 95, 3597–3602.
    Article PubMed CAS Google Scholar
  26. Lacey, D. L., Timms, E., Tan, H. L., et al. (1998) Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Cell 93, 165–176.
    Article PubMed CAS Google Scholar
  27. Wong, B. R., Rho, J., Arron, J., et al. (1997) TRANCE is a novel ligand of the tumor necrosis factor receptor family that activates c-Jun N-terminal kinase in T cells. J. Biol. Chem. 272, 25190–25194.
    Article PubMed CAS Google Scholar
  28. Anderson, D. M., Maraskovsky, E., Billingsley, W. L., et al. (1997) A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function. Nature 390, 175–179.
    Article PubMed CAS Google Scholar
  29. The American Society for Bone and Mineral Research President’s Committee on Nomenclature (2000) Proposed standard nomenclature for new tumor necrosis factor family members involved in the regulation of bone resorption. J. Bone Miner. Res. 15, 2293–2296.
    Google Scholar
  30. Udagawa, N., Takahashi, N., Akatsu, T., et al. (1989) The bone marrow-derived stromal cell lines MC3T3-G2/PA6 and ST2 support osteoclast-like cell differentiation in cocultures with mouse spleen cells. Endocrinology 125, 1805–1813.
    Article PubMed CAS Google Scholar
  31. Quinn, J. M., Morfis, M., Lam, M. H., et al. (1999) Calcitonin receptor antibodies in the identification of osteoclasts. Bone 25, 1–8.
    Article PubMed CAS Google Scholar
  32. Miyazaki, T., Takayanagi, H., Isshiki, M., et al. (2000) In vitro and in vivo suppression of osteoclast function by adenovirus vector-induced csk gene. J. Bone Miner. Res. 15, 41–51.
    Article PubMed CAS Google Scholar
  33. Miyazaki, T., Katagiri, H., Kanegae, Y., et al. (2000) Reciprocal role of ERK and NF-κB pathways in survival and activation of osteoclasts. J. Cell Biol. 148, 333–342.
    Article PubMed CAS Google Scholar

Download references