Runx1/AML1 in Normal and Abnormal Hematopoiesis (original) (raw)
van WijnenAJ, Stein GS, Gergen JP, et al. Nomenclature for Runt- related (RUNX) proteins.Oncogene. 2004;23:4209–4210. ArticleCASPubMed Google Scholar
Yan J, Liu Y, Lukasik SM, Speck NA, Bushweller JH. CBFβ allosterically regulates the Runx1 Runt domain via a dynamic con- formational equilibrium.Nat Struct Mol Biol. 2004;11:901–906. ArticleCASPubMed Google Scholar
Huang G, Shigesada K, Ito K, Wee HJ, Yokomizo T, Ito Y. Dimer- ization with PEBP2β protects RUNX1/AML1 from ubiquitin-pro- teasome-mediated degradation.EMBO J. 2001;20:723–733. ArticleCASPubMedPubMed Central Google Scholar
Lutterbach B, Hiebert SW. Role of the transcription factor AML-1 in acute leukemia and hematopoietic differentiation.Gene. 2000; 245:223–235. ArticleCASPubMed Google Scholar
Mitani K. Leukemogenesis by the chromosomal translocations.Leukemia. 1997;11(suppl 3):294–296. PubMed Google Scholar
Perry C, Eldor A, Soreq H. Runx1/AML1 in leukemia: disrupted association with diverse protein partners.Leuk Res. 2002;26:221–2288. ArticleCASPubMed Google Scholar
Kitabayashi I, Yokoyama A, Shimizu K, Ohki M. Interaction and functional cooperation of the leukemia-associated factors AML1 and p300 in myeloid cell differentiation.EMBO J. 1998;17:2994–30044. ArticleCASPubMedPubMed Central Google Scholar
Yagi R, Chen LF, Shigesada K, Murakami Y, Ito Y. A WW domain- containing yes-associated protein (YAP) is a novel transcriptional co-activator.EMBO J. 1999;18:2551–2562. ArticleCASPubMedPubMed Central Google Scholar
Bruhn L, Munnerlyn A, Grosschedl R. ALY, a context-dependent coactivator of LEF-1 and AML-1, is required for TCRalpha enhancer function.Genes Dev. 1997;11:640–653. ArticleCASPubMed Google Scholar
Durst KL, Hiebert SW. Role of RUNX family members in transcriptional repression and gene silencing.Oncogene. 2004;23:4220–42244. ArticleCASPubMed Google Scholar
Taniuchi I, Osato M, Egawa T, et at. Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development.Cell. 2002;111:621–633. ArticleCASPubMed Google Scholar
Okuda T, van Deursen J, Hiebert SW, Grosveld G, Downing JR. AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis.Cell. 1996;84:321–330. ArticleCASPubMed Google Scholar
Wang Q, Stacy T, Miller JD, et al. The CBFbeta subunit is essential for CBFalpha2 (AML1) function in vivo.Cell. 1996;87:697–708. ArticleCASPubMed Google Scholar
Cai Z, de BruijnM, Ma X, et al. Haploinsufficiency of AML1 affects the temporal and spatial generation of hematopoietic stem cells in the mouse embryo.Immunity. 2000;13:423–431. ArticleCASPubMed Google Scholar
North TE, de Bruijn MF, Stacy T, et al. Runx1 expression marks long-term repopulating hematopoietic stem cells in the midgesta- tion mouse embryo.Immunity. 2002;16:661–672. ArticleCASPubMed Google Scholar
Ichikawa M, Asai T, Saito T, et al. AML-1 is required for megakary- ocytic maturation and lymphocytic differentiation, but not for maintenance of hematopoietic stem cells in adult hematopoiesis [erratum in:Nat Med. 2005;11:102].Nat Med. 2004;10:299–304. ArticleCASPubMed Google Scholar
Hayashi K, Natsume W, Watanabe T, et al. Diminution of the AML1 transcription factor function causes differential effects on the fates of CD4 and CD8 single-positive T cells.J Immunol. 2000; 165:6816–6824. ArticleCASPubMed Google Scholar
Hayashi K, Abe N, Watanabe T, et al. Overexpression of AML1 transcription factor drives thymocytes into the CD8 single-positive lineage.J Immunol. 2001;167:4957–4965. ArticleCASPubMed Google Scholar
Komine O, Hayashi K, Natsume W, et al. The Runx1 transcription factor inhibits the differentiation of naive CD4+ T cells into the Th2 lineage by repressing_GATA3_ expression.J Exp Med. 2003; 198:51–61. ArticleCASPubMedPubMed Central Google Scholar
Miyoshi H, Kozu T, Shimizu K, et al. The t(8;21) translocation in acute myeloid leukemia results in production of an AML1-MTG8 fusion transcript.EMBO J. 1993;12:2715–2721. ArticlePubMedPubMed CentralCAS Google Scholar
Lutterbach B, Westendorf JJ, Linggi B, et al. ETO, a target of t(8;21) in acute leukemia, interacts with the N-CoR and mSin3 corepres- sors.Mol Cell Biol. 1998;18:7176–7184. ArticleCASPubMedPubMed Central Google Scholar
Amann JM, Nip J, Strom DK, et al. ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacety- lases and binds mSin3A through its oligomerization domain.Mol Cell Biol. 2001;21:6470–6483. ArticleCASPubMedPubMed Central Google Scholar
Chevallier N, Corcoran CM, Lennon C, et al. ETO protein of t(8;21) AML is a corepressor for Bcl-6 B-cell lymphoma oncoprotein.Blood. 2004;103:1454–1463. ArticleCASPubMed Google Scholar
Bushweller JH, Liu Y, Chruszcz M, Minor W, Speck NA. Structural and functional basis of the dominant negative phenotype of AML1- ETO, product of the t(8;21) [abstract].Blood. 2003;102:171a. Google Scholar
Vangala RK, Heiss-Neumann MS, Rangatia JS, et al. The myeloid master regulator transcription factor PU.1 is inactivated by AML1- ETO in t(8;21) myeloid leukemia.Blood. 2003;101:270–277. ArticleCASPubMed Google Scholar
Shimizu K, Kitabayashi I, Kamada N, et al. AML1-MTG8 leukemic protein induces the expression of granulocyte colony-stimulating factor (G-CSF) receptor through the up-regulation of CCAAT/ enhancer binding protein epsilon.Blood. 2000;96:288–296. PubMedCAS Google Scholar
Elsasser A, Franzen M, Kohlmann A, et al. The fusion protein AML1-ETO in acute myeloid leukemia with translocation t(8;21) induces c-jun protein expression via the proximal AP-1 site of the c-jun promoter in an indirect, JNK-dependent manner.Oncogene. 2003;22:5646–5657. ArticleCASPubMed Google Scholar
Mulloy JC, Jankovic V, Wunderlich M, et al. AML1-ETO fusion protein up-regulates TRKA mRNA expression in human CD34+ cells, allowing nerve growth factor-induced expansion.Proc Natl Acad Sci USA. 2005;102:4016–4021. ArticleCASPubMedPubMed Central Google Scholar
Zhang J, Kalkum M, Yamamura S, Chait BT, Roeder RG. E protein silencing by the leukemogenic AML1-ETO fusion protein.Science. 2004;305:1286–1289. ArticleCASPubMed Google Scholar
Kitabayashi I, Ida K, Morohoshi F, et al. The AML1-MTG8 leukemic fusion protein forms a complex with a novel member of the MTG8(ETO/CDR) family, MTGR1.Mol Cell Biol. 1998;18:846–8588. ArticleCASPubMedPubMed Central Google Scholar
Kitabayashi I, Yokoyama A, Shimizu K, Ohki M. Interaction and functional cooperation of the leukemia-associated factors AML1 and p300 in myeloid cell differentiation.EMBO J. 1998;17:2994–30044. ArticleCASPubMedPubMed Central Google Scholar
Ibanez V, Sharma A, Buonamici S, et al. AML1-ETO decreases ETO-2 (MTG16) interactions with nuclear receptor corepressor, an effect that impairs granulocyte differentiation.Cancer Res. 2004;64:4547–4554. ArticleCASPubMed Google Scholar
Okuda T, Cai Z, Yang S, et al. Expression of a knocked-in_AML1- ETO_ leukemia gene inhibits the establishment of normal definitive hematopoiesis and directly generates dysplastic hematopoietic progenitors.Blood. 1998;91:3134–3143. PubMedCAS Google Scholar
Yergeau DA, Hetherington CJ, Wang Q, et al. Embryonic lethality and impairment of haematopoiesis in mice heterozygous for an_AML1-ETO_ fusion gene.Nat Genet. 1997;15:303–306. ArticleCASPubMed Google Scholar
Yuan Y, Zhou L, Miyamoto T, et al. AML1-ETO expression is directly involved in the development of acute myeloid leukemia in the presence of additional mutations.Proc Natl Acad Sci USA. 2001;98:10398–10403. ArticleCASPubMedPubMed Central Google Scholar
Rhoades KL, Hetherington CJ, Harakawa N, et al. Analysis of the role of AML1-ETO in leukemogenesis, using an inducible transgenic mouse model.Blood. 2000;96:2108–2115. PubMedCAS Google Scholar
Higuchi M, O’Brien D, Kumaravelu P, Lenny N, Yeoh EJ, Downing JR. Expression of a conditional AML1-ETO oncogene bypasses embryonic lethality and establishes a murine model of human t(8;21) acute myeloid leukemia.Cancer Cell. 2002;1:63–74. ArticleCASPubMed Google Scholar
Mulloy JC, Cammenga J, MacKenzie KL, Berguido FJ, Moore MA, Nimer SD. The AML1-ETO fusion protein promotes the expansion of human hematopoietic stem cells.Blood. 2002;99:15–23. ArticleCASPubMed Google Scholar
de Guzman CG, Warren AJ, Zhang Z, et al. Hematopoietic stem cell expansion and distinct myeloid developmental abnormalities in a murine model of the_AML1-ETO_ translocation.Mol Cell Biol. 2002;22:5506–5517. ArticleCAS Google Scholar
Fenske TS, Pengue G, Mathews V, et al. Stem cell expression of the AML1/ETO fusion protein induces a myeloproliferative disorder in mice.Proc Natl Acad Sci USA. 2004;101:15184–15189. ArticleCASPubMedPubMed Central Google Scholar
Yan M, Burel SA, Peterson LF, et al. Deletion of an AML1-ETO C-terminal NcoR/SMRT-interacting region strongly induces leukemia development.Proc Natl Acad Sci USA. 2004;101:17186–171911. ArticleCASPubMedPubMed Central Google Scholar
Mitani K, Ogawa S, Tanaka T, et al. Generation of the AML1- EVI-1 fusion gene in the t(3;21)(q26;q22) causes blastic crisis in chronic myelocytic leukemia.EMBO J. 1994;13:504–510. ArticlePubMedPubMed CentralCAS Google Scholar
Barjesteh van Waalwijk vanDoorn-Khosrovani S, Erpelinck C, van PuttenWL, et al. High_EVI1_ expression predicts poor survival in acute myeloid leukemia: a study of 319 de novo AML patients.Blood. 2003;101:837–845. ArticleCAS Google Scholar
Fears S, Mathieu C, Zeleznik-Le N, Huang S, Rowley JD, Nucifora G. Intergenic splicing of_MDS1_ and_EVI1_ occurs in normal tissues as well as in myeloid leukemia and produces a new member of the PR domain family.Proc Natl Acad Sci USA. 1996;93:1642–1647. ArticleCASPubMedPubMed Central Google Scholar
Tanaka T, Nishida J, Mitani K, Ogawa S, Yazaki Y, Hirai H. Evi-1 raises AP-1 activity and stimulates c-fos promoter transactivation with dependence on the second zinc finger domain.J Biol Chem. 1994;269:24020–24026. PubMedCAS Google Scholar
Takahashi S, Licht JD. The human promyelocytic leukemia zinc finger gene is regulated by the Evi-1 oncoprotein and a novel guanine- rich site binding protein.Leukemia. 2002;16:1755–1762. ArticleCASPubMed Google Scholar
Yuasa H, Oike Y, Iwama A, et al. Oncogenic transcription factor_Evi1_ regulates hematopoietic stem cell proliferation through_GATA-2_ expression.EMBO J. 2005;24:1976–1987. ArticleCASPubMedPubMed Central Google Scholar
Buonamici S, Li D, Mikhail FM, et al. EVI1 abrogates interferon-α response by selectively blocking PML induction.J Biol Chem. 2005;280:428–436. ArticleCASPubMed Google Scholar
Kurokawa M, Mitani K, Irie K, et al. The oncoprotein Evi-1 represses TGF-β signalling by inhibiting Smad3.Nature. 1998;394:92–96. ArticleCASPubMed Google Scholar
Izutsu K, Kurokawa M, Imai Y, Maki K, Mitani K, Hirai H. The corepressor CtBP interacts with Evi-1 to repress transforming growth factor β signaling.Blood. 2001;97:2815–2282. ArticleCASPubMed Google Scholar
Palmer S, Brouillet JP, Kilbey A, et al. Evi-1 transforming and repressor activities are mediated by CtBP co-repressor proteins.J. Biol Chem. 2001;276:25834–25840. ArticleCASPubMed Google Scholar
Tanaka K, Tanaka T, Kurokawa M, et al. The AML1/ETO(MTG8) and AML1/Evi-1 leukemia-associated chimeric oncoproteins accumulate PEBP2β(CBFβ) in the nucleus more efficiently than wild- type AML1.Blood. 1998;91:1688–1699. PubMedCAS Google Scholar
Tanaka T, Mitani K, Kurokawa M, et al. Dual functions of the AML1/Evi-1 chimeric protein in the mechanism of leukemogene- sis in t(3;21) leukemias.Mol Cell Biol. 1995;15:2383–2392. ArticleCASPubMedPubMed Central Google Scholar
Izutsu K, Kurokawa M, Imai Y, et al. The t(3;21) fusion product, AML1/Evi-1 blocks AML1-induced transactivation by recruiting CtBP.Oncogene. 2002;21:2695–2703. ArticleCASPubMed Google Scholar
Senyuk V, Chakraborty S, Mikhail FM, Zhao R, Chi Y, Nucifora G. The leukemia-associated transcription repressor AML1/MDS1/ EVI1 requires CtBP to induce abnormal growth and differentiation of murine hematopoietic cells.Oncogene. 2002;21:3232–3240. ArticleCASPubMed Google Scholar
Cuenco GM, Nucifora G, Ren R. Human AML1/MDS1/EVI1 fusion protein induces an acute myelogenous leukemia (AML) in mice: a model for human AML.Proc Natl Acad Sci USA. 2000;97:1760–17655. ArticleCASPubMedPubMed Central Google Scholar
Maki K, Yamagata T, Asai T, et al. Dysplastic definitive hematopoiesis in AML1/Evi-1 knock-in embryos.Blood. 2005. In press.
Gamou T, Kitamura E, Hosoda F, et al. The partner gene of AML1 in t(16;21) myeloid malignancies is a novel member of the MTG8(ETO) family.Blood. 1998;91:4028–4037. PubMedCAS Google Scholar
Morohoshi F, Mitani S, Mitsuhashi N, et al. Structure and expression pattern of a human_MTG8/ETO_ family gene,MTGR1.Gene. 2000;241:287–295. ArticleCASPubMed Google Scholar
Kochetkova M, McKenzie OL, Bais AJ, et al.CBFA2T3 (MTG16) is a putative breast tumor suppressor gene from the breast cancer loss of heterozygosity region at 16q24.3.Cancer Res. 2002;62:4599–46044. PubMedCAS Google Scholar
Hoogeveen AT, Rossetti S, Stoyanova V, et al. The transcriptional corepressor MTG16a contains a novel nucleolar targeting sequence deranged in t (16; 21)-positive myeloid malignancies.Oncogene. 2002;21:6703–6712. ArticleCASPubMed Google Scholar
Golub TR, Barker GF, Bohlander SK, et al. Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia.Proc NatlAcad Sci USA. 1995;92:4917–4921. ArticleCAS Google Scholar
Hiebert SW, Sun W, Davis JN, et al. The t(12;21) translocation converts AML-1B from an activator to a repressor of transcription.Mol Cell Biol. 1996;16:1349–1355. ArticleCASPubMedPubMed Central Google Scholar
Fears S, Gavin M, Zhang DE, et al. Functional characterization of_ETV6_ and_ETV6/CBFA2_ in the regulation of the_MCSFR_ proximal promoter.Proc Natl Acad Sci USA. 1997;94:1949–1954. ArticleCASPubMedPubMed Central Google Scholar
Fenrick R, Amann JM, Lutterbach B, et al. Both TEL and AML-1 contribute repression domains to the t(12;21) fusion protein.Mol Cell Biol. 1999;19:6566–6574. ArticleCASPubMedPubMed Central Google Scholar
Sawinska M, Ladon D. Mechanism, detection and clinical significance of the reciprocal translocation t(12;21)(p12;q22) in the children suffering from acute lymphoblastic leukaemia.Leuk Res. 2004;28:35–42. ArticleCASPubMed Google Scholar
Guidez F, Petrie K, Ford AM, et al. Recruitment of the nuclear receptor corepressor N-CoR by the TEL moiety of the childhood leukemia-associated TEL-AML1 oncoprotein.Blood. 2000;96:2557–25611. PubMedCAS Google Scholar
Gunji H, Waga K, Nakamura F, et al. TEL/AML1 shows dominant- negative effects over TEL as well as AML1.Biochem Biophys Res Commun. 2004;322:623–630. ArticleCASPubMed Google Scholar
Wang LC, Swat W, Fujiwara Y, et al. The_TEL/ETV6_ gene is required specifically for hematopoiesis in the bone marrow.Genes Dev. 1998; 12:2392–2402. ArticleCASPubMedPubMed Central Google Scholar
Andreasson P, Schwaller J, Anastasiadou E, Aster J, Gilliland DG. The expression of_ETV6/CBFA2 (TEL/AML1)_ is not sufficient for the transformation of hematopoietic cell lines in vitro or the induction of hematologic disease in vivo.Cancer Genet Cytogenet. 2001; 130:93–104. ArticleCASPubMed Google Scholar
Bernardin F, Yang Y, Cleaves R, et al. TEL-AML1, expressed from t(12;21) in human acute lymphocytic leukemia, induces acute leukemia in mice.Cancer Res. 2002;62:3904–3908. PubMedCAS Google Scholar
Tsuzuki S, Seto M, Greaves M, Enver T. Modeling first-hit functions of the t(12;21)TEL-AML1 translocation in mice.Proc Natl Acad Sci USA. 2004;101:8443–8448. ArticleCASPubMedPubMed Central Google Scholar
Song WJ, Sullivan MG, Legare RD, et al. Haploinsufficiency of_CBFA2_ causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia.Nat Genet. 1999;23:166–1755. ArticleCASPubMed Google Scholar
Osato M. Point mutations in the_RUNX1/AML1_ gene: another actor in RUNX leukemia.Oncogene. 2004;23:4284–4296. ArticleCASPubMed Google Scholar
Osato M, Asou N, Abdalla E, et al. Biallelic and heterozygous point mutations in the Runt domain of the_AMLl/PEBP2αB_ gene associated with myeloblastic leukemias.Blood. 1999;93:1817–18244. PubMedCAS Google Scholar
Harada H, Harada Y, Niimi H, Kyo T, Kimura A, Inaba T. High incidence of somatic mutations in the_AML1/RUNX1_ gene in myelodysplastic syndrome and low blast percentage myeloid leukemia with myelodysplasia.Blood. 2004;103:2316–2324. ArticleCASPubMed Google Scholar
Michaud J, Wu F, Osato M, et al. In vitro analyses of known and novel RUNX1/AML1 mutations in dominant familial platelet dis- order with predisposition to acute myelogenous leukemia: impli- cations for mechanisms of pathogenesis.Blood. 2002;99:1364–13722. ArticleCASPubMed Google Scholar
Kurokawa M, Tanaka T, Tanaka K, et al. Overexpression of the AML1 proto-oncoprotein in NIH3T3 cells leads to neoplastic transformation depending on the DNA-binding and transactivational potencies.Oncogene. 1996;12:883–892. PubMedCAS Google Scholar