Endogenous Matrix Metalloproteinase (MMP)-3 and MMP-9 Promote the Differentiation and Migration of Adult Neural Progenitor Cells in Response to Chemokines (original) (raw)

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Department of Neurosciences, University of New Mexico School of Medicine

, Albuquerque, New Mexico,

USA

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Department of Neurosciences, University of New Mexico School of Medicine

, Albuquerque, New Mexico,

USA

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,

Department of Neurosciences, University of New Mexico School of Medicine

, Albuquerque, New Mexico,

USA

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,

Department of Neurosciences, University of New Mexico School of Medicine

, Albuquerque, New Mexico,

USA

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,

Department of Neurosciences, University of New Mexico School of Medicine

, Albuquerque, New Mexico,

USA

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Department of Neurosciences, University of New Mexico School of Medicine

, Albuquerque, New Mexico,

USA

Correspondence: Xinyu Zhao, Ph.D., Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, New Mexico 87131, USA. Telephone: 505-272-4410; Fax: 505-272-8082; e-mail: xzhao@salud.unm.edu

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Accepted:

11 September 2008

Published:

25 September 2008

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Basam Z. Barkho, Ari E. Munoz, Xuekun Li, Lu Li, Lee Anna Cunningham, Xinyu Zhao, Endogenous Matrix Metalloproteinase (MMP)-3 and MMP-9 Promote the Differentiation and Migration of Adult Neural Progenitor Cells in Response to Chemokines, Stem Cells, Volume 26, Issue 12, December 2008, Pages 3139–3149, https://doi.org/10.1634/stemcells.2008-0519
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Abstract

Adult neurogenesis is regulated by both intrinsic programs and extrinsic stimuli. The enhanced proliferation of adult neural stem/progenitor cells (aNPCs) in the subventricular zone and the migration of neuroblasts toward the ischemic region in adult brains present a unique challenge as well as an opportunity to understand the molecular mechanisms underlying the extrinsic cue-induced neurogenic responses. Matrix metalloproteinases (MMPs) are a family of proteinases known to play a role in extracellular matrix remodeling and cell migration. However, their presence in aNPCs and their potential function in injury-induced aNPC migration remain largely unexplored. Here we demonstrate that in response to two injury-induced chemokines, stromal cell-derived factor 1 (SDF-1) and vascular endothelial growth factor, aNPCs differentiated into migratory cells that expressed increased levels of MMP-3 and MMP-9. Whereas differentiated neuroblasts and a subpopulation of astrocytes migrated toward the chemokines, undifferentiated progenitors did not migrate. Blocking the expression of MMP-3 or MMP-9 in aNPCs interfered with both the differentiation of aNPCs and chemokine-induced cell migration. Thus, endogenous MMPs expressed by aNPCs are important for mediating their neurogenic response to extrinsic signals.

Disclosure of potential conflicts of interest is found at the end of this article.

Copyright © 2008 AlphaMed Press

This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open\_access/funder\_policies/chorus/standard\_publication\_model)

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