PCAPAM50: Enhanced 'PAM50' Subtyping of Breast Cancer (original) (raw)
Accurate classification of breast cancer tumors based on gene expression data is not a trivial task, and it lacks standard practices.The 'PAM50' classifier, which uses 50 gene centroid correlation distances to classify tumors, faces challenges with balancing estrogen receptor (ER) status and gene centering. The 'PCAPAM50' package leverages principal component analysis and iterative 'PAM50' calls to create a gene expression-based ER-balanced subset for gene centering, avoiding the use of protein expression-based ER data resulting into an enhanced Breast Cancer subtyping.
| Version: | 1.0.1 |
|---|---|
| Imports: | Biobase, lattice, ComplexHeatmap, impute |
| Suggests: | testthat, knitr, rmarkdown |
| Published: | 2024-07-09 |
| DOI: | 10.32614/CRAN.package.PCAPAM50 |
| Author: | Praveen-Kumar Raj-Kumar [aut, cre, cph], Boyi Chen [aut], Ming-Wen Hu [aut], Tyler Hohenstein [aut], Jianfang Liu [aut], Craig D. Shriver [aut], Xiaoying Lin [aut, cph], Hai Hu [aut, cph] |
| Maintainer: | Praveen-Kumar Raj-Kumar <p.rajkumar at wriwindber.org> |
| License: | GPL (≥ 3) |
| Copyright: | 2024 Windber Research Institute, Windber, PA - 15963. All Rights Reserved. |
| NeedsCompilation: | no |
| Citation: | PCAPAM50 citation info |
| Materials: | |
| CRAN checks: | PCAPAM50 results |
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