Association of Sleep Characteristics and Cognition in Older Community-Dwelling Men: the MrOS Sleep Study (original) (raw)

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1Research Institute, California Pacific Medical Center, San Francisco, CA

*Address correspondence to: Terri Blackwell, MA, San Francisco Coordinating Center, 185 Berry Street, Lobby 5, Suite 5700, San Francisco, CA 94107; Tel: (415) 600-7412; Fax: (415) 514-8150; E-mail: tblackwell@sfcc-cpmc.net

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2Departments of Psychiatry, Neurology, and Epidemiology, University of California, San Francisco, San Francisco, CA and the San Francisco VA Medical Center

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3Department of Psychiatry, University of California, San Diego, La Jolla, CA

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4Departments of Medicine, Brigham and Women's Hospital and Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA

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Kristine E. Ensrud, MD MPH

5Center for Chronic Disease Outcomes Research, Veterans Affairs Medical Center, Minneapolis, MN; Department of Medicine and Division of Epidemiology & Community Health, University of Minnesota, Minneapolis, MN

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6Stanford Prevention Research Center, Department of Medicine, Stanford University School of Medicine, Stanford, CA

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1Research Institute, California Pacific Medical Center, San Francisco, CA

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1Research Institute, California Pacific Medical Center, San Francisco, CA

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for the Osteoporotic Fractures in Men (MrOS) Study Group

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Received:

01 December 2010

Revision received:

01 April 2011

Published:

01 October 2011

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Terri Blackwell, Kristine Yaffe, Sonia Ancoli-Israel, Susan Redline, Kristine E. Ensrud, Marcia L. Stefanick, Alison Laffan, Katie L. Stone, for the Osteoporotic Fractures in Men (MrOS) Study Group, Association of Sleep Characteristics and Cognition in Older Community-Dwelling Men: the MrOS Sleep Study, Sleep, Volume 34, Issue 10, 1 October 2011, Pages 1347–1356, https://doi.org/10.5665/SLEEP.1276
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Abstract

Study Objectives:

To examine the association of objectively and subjectively measured sleep characteristics with cognition in older men.

Design:

A population-based cross-sectional study.

Setting:

6 centers in the United States.

Participants:

3,132 community-dwelling older men (mean age 76.4 ± 5.6 years).

Measurements and Results:

Objectively measured sleep predictors from wrist actigraphy were total sleep time (TST), sleep efficiency (SE), and wake after sleep onset (WASO). Subjective sleep predictors were self-reported poor sleep (Pittsburgh Sleep Quality Index [PSQI] > 5), excessive daytime sleepiness (EDS, Epworth Sleepiness Scale Score > 10), and TST. Cognitive outcomes were measured with the Modified Mini-Mental State examination (3MS), the Trails B test, and the Digit Vigilance Test (DVT). After adjustment for multiple potential confounders, WASO was modestly related to poorer cognition. Compared to those with WASO < 90 min, men with WASO ≥ 90 min took 6.1 sec longer to complete the Trails B test and had a 0.9-point worse 3MS score, on average (P < 0.05). Actigraphically measured long sleepers had a slightly worse 3MS score compared to those with 7-8 h of sleep, but had similar Trails B and DVT completion times. Compared to those who self-reported sleeping 7-8 h, long sleepers (> 8 h) on average took 8.6 sec more to complete the Trails B test, had a 0.6-point worse 3MS score, and took 46 sec longer to complete the DVT (P < 0.05). PSQI and EDS were not independently related to cognitive outcomes.

Conclusions:

There were modest cross-sectional associations of WASO and self-reported long sleep with cognition among older community-dwelling men. EDS and PSQI were not related to cognition.

© 2011 Associated Professional Sleep Societies, LLC.

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